Phenotypes associated with this allele

• Allele Symbol: Mobp^tm1Sak
• Allele Name: targeted mutation 1, Saburo Sakoda
• Allele ID: MGI:3042483
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mobp^tm1Sak/Mobp^tm1Sak	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	MGI:3043019

Genotype
MGI:3043019

hm1

• Allelic Composition: Mobp^tm1Sak/Mobp^tm1Sak
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:89416 )

N • no gross behavioral anomalies

nervous system

abnormal myelination ( J:89416 )

• while the formation of compact myelin was normal, the radial component was abnormally straight (instead of zig-zag as in wild-type)

• in response to a dysmyelinating agent, hexachlorophene (HCP), there was an increased frequency of vacuolation relative to wild-type controls and a widening of the major dense lines which was not observed in wild-type controls