Phenotypes associated with this allele

• Allele Symbol: Kcna3^tm1Gvd
• Allele Name: targeted mutation 1, Gary V Desir
• Allele ID: MGI:3042596
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcna3^tm1Gvd/Kcna3^tm1Gvd	involves: 129S1/Sv * C57BL/6	MGI:3043097

Genotype
MGI:3043097

hm1

• Allelic Composition: Kcna3^tm1Gvd/Kcna3^tm1Gvd
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:89447 )

decreased susceptibility to diet-induced obesity ( J:89447 )

• while both male and female mice gained weight on a high fat diet, they gained significantly less than control mice and did not become obese

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:89447 )

• while both male and female mice gained weight on a high fat diet, they gained significantly less than control mice and did not become obese

abnormal glucose homeostasis ( J:88651 )

• increased baseline and insulin-stimulated glucose uptake by adipose tissue and skeletal muscle

decreased circulating insulin level ( J:88651 )

• decreased in both non-fasting and fasting condition

increased insulin sensitivity ( J:88651 )

• increased peripheral insulin sensitivity, putatively due to increased surface expression of SLC2A4 (GLUT4)

increased basal metabolism ( J:89447 )

• increased basal metabolic rate relative to controls

• food intake did not significantly differ from that of controls

muscle

increased skeletal muscle cell glucose uptake ( J:88651 )

• increased baseline and insulin-stimulated glucose uptake by skeletal muscle

cellular

increased skeletal muscle cell glucose uptake ( J:88651 )

• increased baseline and insulin-stimulated glucose uptake by skeletal muscle