Phenotypes associated with this allele

• Allele Symbol: Bmp4^tm1.1Jfm
• Allele Name: targeted mutation 1.1, James F Martin
• Allele ID: MGI:3042751
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bmp4^tm1Jfm/Bmp4^tm1.1Jfm Tg(Prrx1-cre)1Cjt/0	involves: 129S4/SvJaeSor	MGI:3043045
cn2	Bmp4^tm1Jfm/Bmp4^tm1.1Jfm Nkx2-5^tm1(cre)Rjs/Nkx2-5^+	involves: 129S4/SvJaeSor * 129S7/SvEvBrd	MGI:3043044

Genotype
MGI:3043045

cn1

• Allelic Composition: Bmp4^tm1Jfm/Bmp4^tm1.1Jfm; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

conotruncal ridge hypoplasia ( J:89237 )

• severely reduced outflow tract cushions, which developed into a shortened outflow tract

Genotype
MGI:3043044

cn2

• Allelic Composition: Bmp4^tm1Jfm/Bmp4^tm1.1Jfm; Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
• Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:89237 )

• most mice died by E13.5, although an occasional fetus survived to E18.5, putatively due to variability in the expression of cre recombinase

• peripheral edema that was often associated with pericardial effusion indicated that lethality was secondary to heart failure

cardiovascular system

abnormal pharyngeal arch artery morphology ( J:89237 )

• severe defects in the architecture of the brancial arch artery due to impaired remodeling

• variable branching and abnormal regression and remodeling

abnormal pulmonary artery morphology ( J:89237 )

• only one pulmonary artery originates from the ductus arteriosis and the fate of the second pulmonary artery is not clear

aortopulmonary window ( J:89237 )

• majority exhibited a proximal aortopulmonary window, in which the proximal aspect of the outflow tract septum failed to form

abnormal aortic arch and aortic arch branch attachment ( J:89237 )

• the left carotid artery branched either from the right brachiocephalic artery in the most severely affected embryos or directly from the aorta in more mildly affected embryos

interrupted aortic arch, type b ( J:89237 )

• interruption (type B) of the aorta between the left carotid and the left subclavian arteries

persistent truncus arteriosus ( J:89237 )

abnormal heart development ( J:89237 )

abnormal conotruncal ridge morphology ( J:89237 )

• growth was delayed and the cushions were hypoplastic

• cell proliferation is reduced in the cushion mesenchyme, relative to wild-type

conotruncal ridge hypoplasia ( J:89237 )

perimembraneous ventricular septal defect ( J:89237 )

• observed in all examined fetuses

• putatively due to a defect in the conotruncal mesenchyme

semilunar valve hypoplasia ( J:89237 )

• hypoplastic semilunar valves

pericardial effusion ( J:89237 )

• peripheral edema that was often associated with pericardial effusion

homeostasis/metabolism

pericardial effusion ( J:89237 )

• peripheral edema that was often associated with pericardial effusion

hydrops fetalis ( J:89237 )

• peripheral edema that was often associated with pericardial effusion

craniofacial

abnormal pharyngeal arch artery morphology ( J:89237 )

• severe defects in the architecture of the brancial arch artery due to impaired remodeling

• variable branching and abnormal regression and remodeling

embryo

abnormal pharyngeal arch artery morphology ( J:89237 )

• severe defects in the architecture of the brancial arch artery due to impaired remodeling

• variable branching and abnormal regression and remodeling