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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Scn10a-cre)1Rkun
transgene insertion 1, Rohini Kuner
MGI:3042874
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fstl1tm1Nju/Fstl1tm1Nju
Tg(Scn10a-cre)1Rkun/0 		involves: 129 * C57BL/6 * DBA MGI:5440896
cn2
 		Gabra2tm1Uru/Gabra2tm1Uru
Tg(Scn10a-cre)1Rkun/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA/2 MGI:5140579
cn3
 		Tlx3tm2.1Qima/Tlx3tm2.1Qima
Tg(Scn10a-cre)1Rkun/0 		involves: 129S4/SvJae * C57BL/6 * DBA/2 * SJL MGI:5433368
cn4
 		Kcnt1tm1.1Acsc/Kcnt1tm1.1Acsc
Tg(Scn10a-cre)1Rkun/0 		involves: BALB/cJ * C57BL/6 * C57BL/6N * DBA/2 MGI:5896605
cn5
 		Mycbp2tm1.1Klsc/Mycbp2tm1.1Klsc
Tg(Scn10a-cre)1Rkun/0 		involves: C57BL/6 * DBA/2 MGI:4939606
cn6
 		Gabra2tm1Uru/Gabra2tm2.1Uru
Tg(Scn10a-cre)1Rkun/0 		involves: C57BL/6 * DBA/2 * SJL MGI:5140581
cn7
 		Gabra2tm2.1Uru/Gabra2tm2.1Uru
Tg(Scn10a-cre)1Rkun/0 		involves: C57BL/6 * DBA/2 * SJL MGI:5140578


Genotype
MGI:5440896
cn1
Allelic
Composition		 Fstl1tm1Nju/Fstl1tm1Nju
Tg(Scn10a-cre)1Rkun/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fstl1tm1Nju mutation (0 available); any Fstl1 mutation (46 available)
Tg(Scn10a-cre)1Rkun mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dorsal root ganglion morphology ( J:188549 )
• small dorsal root ganglion neurons have a reduction in the number of FSTL1-immunoreactive vesicles
abnormal action potential ( J:188549 )
• firing rates are elevated in wide-dynamic range neurons and both innocuous (pressure) and noxious (pinch) stimuli induce a similar increase in firing rate
increased excitatory postsynaptic current frequency ( J:188549 )
• the baseline of spontaneous excitatory postsynaptic current frequency in lamina II neurons is elevated
• the K+ induced frequency is increased

behavior/neurological
hyperresponsive to tactile stimuli ( J:188549 )
• reduced response threshold to von Frey mechanical stimuli applied to the hindpaw
decreased chemical nociceptive threshold ( J:188549 )
• display exaggerated responses in both first and second phases of the nociceptive reaction after intradermal injection of 0.5% formalin
decreased thermal nociceptive threshold ( J:188549 )
• reduced response latencies during radiant heat testing




Genotype
MGI:5140579
cn2
Allelic
Composition		 Gabra2tm1Uru/Gabra2tm1Uru
Tg(Scn10a-cre)1Rkun/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra2tm1Uru mutation (0 available); any Gabra2 mutation (36 available)
Tg(Scn10a-cre)1Rkun mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased chemically-elicited antinociception ( J:173378 )
• diazepam (DZP)-treated mice exhibit a profound reduction in the antihyperalgesia effect on inflammatory and neuropathic thermal and mechanical hyperalgesia compared with similarly treated wild-type mice

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:173378 )
• diazepam (DZP)-treated mice exhibit a profound reduction in the antihyperalgesia effect on inflammatory and neuropathic thermal and mechanical hyperalgesia compared with similarly treated wild-type mice




Genotype
MGI:5433368
cn3
Allelic
Composition		 Tlx3tm2.1Qima/Tlx3tm2.1Qima
Tg(Scn10a-cre)1Rkun/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Scn10a-cre)1Rkun mutation (0 available)
Tlx3tm2.1Qima mutation (0 available); any Tlx3 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron physiology ( J:186470 )
• at P30 lumbar in the dorsal root ganglion the molecular identity of IB4+ neurons is modified resulting in impaired segregation of TrkA+ and Ret+ neurons
• decrease or absence of expression of genes encoding sensory channels and receptors involved with pain, itch and/or temperature sensation at P30 in the lumbar and thoracic dorsal root ganglia




Genotype
MGI:5896605
cn4
Allelic
Composition		 Kcnt1tm1.1Acsc/Kcnt1tm1.1Acsc
Tg(Scn10a-cre)1Rkun/0
Genetic
Background		 involves: BALB/cJ * C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnt1tm1.1Acsc mutation (0 available); any Kcnt1 mutation (67 available)
Tg(Scn10a-cre)1Rkun mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal mechanical nociception ( J:218978 )
• increased mechanical hypersensitivity after spared nerve injury used to induce a neuropathic pain model
• however, inflammatory pain behavior is normal




Genotype
MGI:4939606
cn5
Allelic
Composition		 Mycbp2tm1.1Klsc/Mycbp2tm1.1Klsc
Tg(Scn10a-cre)1Rkun/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mycbp2tm1.1Klsc mutation (0 available); any Mycbp2 mutation (224 available)
Tg(Scn10a-cre)1Rkun mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal spinal cord morphology ( J:168745 )
• the medial region of lamina II is enlarged in the spinal cord compared with wild-type mice

behavior/neurological
decreased thermal nociceptive threshold ( J:168745 )
• mice exhibit prolonged formalin-induced hyperphagia compared with wild-type mice
• however, mice exhibit normal mustard oil-induced desensitization and behavioral response to mechanical stimuli




Genotype
MGI:5140581
cn6
Allelic
Composition		 Gabra2tm1Uru/Gabra2tm2.1Uru
Tg(Scn10a-cre)1Rkun/0
Genetic
Background		 involves: C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra2tm1Uru mutation (0 available); any Gabra2 mutation (36 available)
Gabra2tm2.1Uru mutation (1 available); any Gabra2 mutation (36 available)
Tg(Scn10a-cre)1Rkun mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased chemically-elicited antinociception ( J:173378 )
• diazepam (DZP)-treated mice exhibit a reduction in the antihyperalgesia effect on inflammatory mechanical hyperalgesia compared with similarly treated wild-type mice that is not as severe as in Gabra2tm1Uru/Gabra2tm1Uru Tg(Scn10a-cre)1Rkun
• however, DZP-induced analgesia of neuropathic mechanical nociception is normal

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:173378 )
• diazepam (DZP)-treated mice exhibit a reduction in the antihyperalgesia effect on inflammatory mechanical hyperalgesia compared with similarly treated wild-type mice that is not as severe as in Gabra2tm1Uru/Gabra2tm1Uru Tg(Scn10a-cre)1Rkun
• however, DZP-induced analgesia of neuropathic mechanical nociception is normal




Genotype
MGI:5140578
cn7
Allelic
Composition		 Gabra2tm2.1Uru/Gabra2tm2.1Uru
Tg(Scn10a-cre)1Rkun/0
Genetic
Background		 involves: C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra2tm2.1Uru mutation (1 available); any Gabra2 mutation (36 available)
Tg(Scn10a-cre)1Rkun mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal CNS synaptic transmission ( J:173378 )
• mice treated with DZP and a low concentration of muscimol fail to exhibit a drop in the rate of successful transmission unlike similarly treated wild-type mice
• DZP-potentiated dorsal root potential is strongly reduced compared to in wild-type mice
• however, bicuculline-induced dorsal root potential size and sensitivity
abnormal GABA-mediated receptor currents ( J:173378 )
• the amplitudes of GABAergic membrane currents evoked by DZP are reduced compared to in wild-type mice
• however, muscimol induces normal amplitudes of GABAergic membrane currents

behavior/neurological
decreased chemically-elicited antinociception ( J:173378 )
• DZP-treated mice exhibit a reduction in the antihyperalgesia effect on inflammatory thermal and mechanical hyperalgesia compared with similarly treated wild-type mice that is not as severe as in Gabra2tm1Uru/Gabra2tm1Uru Tg(Scn10a-cre)1Rkun
• however, DZP-induced analgesia of neuropathic thermal and mechanical nociception is normal

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:173378 )
• diazepam (DZP)-treated mice exhibit a reduction in the antihyperalgesia effect on inflammatory thermal and mechanical hyperalgesia compared with similarly treated wild-type mice that is not as severe as in Gabra2tm1Uru/Gabra2tm1Uru Tg(Scn10a-cre)1Rkun
• however, DZP-induced analgesia of neuropathic thermal and mechanical nociception is normal




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11/12/2024
MGI 6.24 		The Jackson Laboratory