All Phenotypes Lrp6<Gw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lrp6^Gw
Gwazi
MGI:3043026

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrp6^Gw/Lrp6^Gw	involves: 101/H * BALB/c * C3H/HeH	MGI:4947307
hm2	Lrp6^Gw/Lrp6^Gw	involves: 101/H * BALB/cOlaHsd * C3H/HeH	MGI:3057017
ht3	Lrp6^Gw/Lrp6⁺	involves: 101/H * BALB/c * C3H/HeH	MGI:4947303
ht4	Lrp6^Gw/Lrp6⁺	involves: 101/H * BALB/cOlaHsd * C3H/HeH	MGI:3057016
cx5	Ctnnb1^Bfc/Ctnnb1⁺ Dkk1^tm1Lmgd/Dkk1⁺ Lrp6^Gw/Lrp6⁺	either: (involves: 101/H * 129 * BALB/cCrl * C3H) or (involves: 101/H * 129 * BALB/cCrl * C3H * C57BL/6)	MGI:4947311
cx6	Ctnnb1^Bfc/Ctnnb1⁺ Lrp6^Gw/Lrp6⁺	either: (involves: 101/H * BALB/cCrl * C3H) or (involves: 101/H * BALB/cCrl * C3H * C57BL/6)	MGI:4947310
cx7	Dkk1^tm1Lmgd/Dkk1⁺ Lrp6^Gw/Lrp6⁺	involves: 101/H * 129 * BALB/c * C3H	MGI:4947305
cx8	Dkk1^tm1Lmgd/Dkk1⁺ Lrp6^Gw/Lrp6^Gw	involves: 101/H * 129 * BALB/c * C3H	MGI:4947306
cx9	Lrp6^Gw/Lrp6⁺ Wnt3^tm1Brd/Wnt3⁺	involves: 101/H * 129S7/SvEvBrd * BALB/c * C3H	MGI:4947304

Allelic Composition	Lrp6^Gw/Lrp6^Gw
Genetic Background	involves: 101/H * BALB/c * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6^Gw mutation (0 available); any Lrp6 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

forebrain hypoplasia ( J:170646 )

• at E9.5 and E10.5, 39% of mice exhibit reduced forebrain size compared with wild-type mice

abnormal telencephalon morphology ( J:170646 )

• mice exhibit reduced rostral and dorsal telencephalon size compared with wild-type mice

limbs/digits/tail

kinked tail ( J:170646 )

• 86% of mice exhibit bent tails unlike wild-type mice

growth/size/body

abnormal head morphology ( J:170646 )

• 30-39% of mice exhibit head malformations compared with wild-type mice

Allelic Composition	Lrp6^Gw/Lrp6^Gw
Genetic Background	involves: 101/H * BALB/cOlaHsd * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6^Gw mutation (0 available); any Lrp6 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:93195 )

growth/size/body

decreased embryo size ( J:93195 )

nervous system

abnormal forebrain development ( J:93195 )

• forebrain defect at E9.5

exencephaly ( J:93195 )

• observed at E12.5

Allelic Composition	Lrp6^Gw/Lrp6⁺
Genetic Background	involves: 101/H * BALB/c * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6^Gw mutation (0 available); any Lrp6 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

kinked tail ( J:170646 )

• in more than half of mice

• 68% of mice exhibit bent tails unlike wild-type mice

nervous system

abnormal forebrain morphology ( J:170646 )

• in 10% of mice

growth/size/body

abnormal head morphology ( J:170646 )

• in 33% of mice

Allelic Composition	Lrp6^Gw/Lrp6⁺
Genetic Background	involves: 101/H * BALB/cOlaHsd * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6^Gw mutation (0 available); any Lrp6 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

kinked tail ( J:93195 )

• crooked tail

Allelic Composition	Ctnnb1^Bfc/Ctnnb1⁺ Dkk1^tm1Lmgd/Dkk1⁺ Lrp6^Gw/Lrp6⁺
Genetic Background	either: (involves: 101/H * 129 * BALB/cCrl * C3H) or (involves: 101/H * 129 * BALB/cCrl * C3H * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^Bfc mutation (3 available); any Ctnnb1 mutation (49 available)
Dkk1^tm1Lmgd mutation (0 available); any Dkk1 mutation (18 available)
Lrp6^Gw mutation (0 available); any Lrp6 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

caudal body truncation ( J:170646 )

• 23% of mice exhibit complete head truncation unlike wild-type mice

growth/size/body

abnormal head size ( J:170646 )

• all mice exhibit head reduction defects unlike wild-type mice

Allelic Composition	Ctnnb1^Bfc/Ctnnb1⁺ Lrp6^Gw/Lrp6⁺
Genetic Background	either: (involves: 101/H * BALB/cCrl * C3H) or (involves: 101/H * BALB/cCrl * C3H * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^Bfc mutation (3 available); any Ctnnb1 mutation (49 available)
Lrp6^Gw mutation (0 available); any Lrp6 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal head size ( J:170646 )

• 86% of mice exhibit head reduction defects unlike wild-type mice

Allelic Composition	Dkk1^tm1Lmgd/Dkk1⁺ Lrp6^Gw/Lrp6⁺
Genetic Background	involves: 101/H * 129 * BALB/c * C3H

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1^tm1Lmgd mutation (0 available); any Dkk1 mutation (18 available)
Lrp6^Gw mutation (0 available); any Lrp6 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

kinked tail ( J:170646 )

• in all mice

growth/size/body

abnormal head morphology ( J:170646 )

• in 40-43% of mice

Allelic Composition	Dkk1^tm1Lmgd/Dkk1⁺ Lrp6^Gw/Lrp6^Gw
Genetic Background	involves: 101/H * 129 * BALB/c * C3H

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal head morphology ( J:170646 )

• in 79% of mice

Allelic Composition	Lrp6^Gw/Lrp6⁺ Wnt3^tm1Brd/Wnt3⁺
Genetic Background	involves: 101/H * 129S7/SvEvBrd * BALB/c * C3H

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6^Gw mutation (0 available); any Lrp6 mutation (95 available)
Wnt3^tm1Brd mutation (0 available); any Wnt3 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

kinked tail ( J:170646 )

• in 22% of mice

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