Phenotypes associated with this allele

• Allele Symbol: Dms
• Allele Name: dominant male sterility
• Allele ID: MGI:3043043
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dms/Dms^+	involves: C57BL/6 * DBA/2	MGI:3043062

Genotype
MGI:3043062

ht1

• Allelic Composition: Dms/Dms⁺
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:75005 )

N • male mating behavior was normal and vaginal plugs were produced

cellular

azoospermia ( J:75005 )

♂ • sperm in the cauda epididymis were all dead

♂ • pronounced absence of sperm in the epididymal duct

arrest of male meiosis ( J:75005 )

♂ • possibly arrested around metaphase 1 of meiosis

reproductive system

abnormal spermatogenesis ( J:75005 )

♂

azoospermia ( J:75005 )

♂ • sperm in the cauda epididymis were all dead

♂ • pronounced absence of sperm in the epididymal duct

arrest of male meiosis ( J:75005 )

♂ • possibly arrested around metaphase 1 of meiosis

abnormal spermiogenesis ( J:75005 )

♂ • degenerating germ cells

♂ • abundance of apoptotic cells among spermatocytes

♂ • most degeneration was in M-I spermatocytes

♂ • degeneration of spermatids as well but to a lesser extent

abnormal male reproductive system morphology ( J:75005 )

♂

abnormal testis morphology ( J:75005 )

♂ • testes of normal size

♂ • few spermatids but many meiotic metaphase I figures

♂ • progressive degeneration of seminiferous tubules between 6 and 16 weeks was minimal

male infertility ( J:75005 )

♂ • all heterozygous males are sterile

♂ • however, females are fertile

endocrine/exocrine glands

abnormal testis morphology ( J:75005 )

♂ • testes of normal size

♂ • few spermatids but many meiotic metaphase I figures

♂ • progressive degeneration of seminiferous tubules between 6 and 16 weeks was minimal