Phenotypes associated with this allele

• Allele Symbol: Cdk11b^tm1Vjk
• Allele Name: targeted mutation 1, Vincent J Kidd
• Allele ID: MGI:3043373
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk11b^tm1Vjk/Cdk11b^tm1Vjk	involves: 129S6/SvEv * C57BL/6	MGI:3043377

Genotype
MGI:3043377

hm1

• Allelic Composition: Cdk11b^tm1Vjk/Cdk11b^tm1Vjk
• Genetic Background: involves: 129S6/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:89908 )

• homozygous embryos die between E3.5 (when the expected number of homozygous embryos are found) and E7.5 (when no homozygous embryos are found)

• embryos die in utero due to apoptosis of the blastocyst cells between E3.5 and E4.0

cellular

increased embryonic tissue cell apoptosis ( J:89908 )

• extensive apoptosis is seen in E3.5 homozygous embryos after only 2 - 3 hours in culture while only rare apoptotic cells are seen in wild-type embryos

decreased cell proliferation ( J:89908 )

• more cells from E3.5 homozygous embryos (50 - 60%) are positive for a mitosis-specific marker compared to wild-type (~10%) suggesting null embryos arrest in mitosis before E3.5

embryo

increased embryonic tissue cell apoptosis ( J:89908 )

• extensive apoptosis is seen in E3.5 homozygous embryos after only 2 - 3 hours in culture while only rare apoptotic cells are seen in wild-type embryos

failure of blastocyst to hatch from the zona pellucida ( J:89908 )

• in culture, E2.5 - E3.5 homozygous embryos fail to hatch out of the zona pellucida

embryonic growth arrest ( J:89908 )

• at E2.5 homozygous embryos appear identical to wild-type embryos

• at E3.5 homozygous embryos fail to form fully expanded blastocysts and appear retarded at the morula stage