Phenotypes associated with this allele

• Allele Symbol: Mmel1^tm1Ldg
• Allele Name: targeted mutation 1, Luc DesGroseillers
• Allele ID: MGI:3043380
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mmel1^tm1Ldg/Mmel1^tm1Ldg	involves: 129S/SvEv * MF1	MGI:3043383

Genotype
MGI:3043383

hm1

• Allelic Composition: Mmel1^tm1Ldg/Mmel1^tm1Ldg
• Genetic Background: involves: 129S/SvEv * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

male infertility ( J:89881 )

♂ • about 20% of homozygous males fail to produce any progeny

reduced male fertility ( J:89881 )

♂ • homozygous males mated to heterozygous females produce an average of 4.7 pups/litter compared to 8.9 pups/litter for wild-type males, this average does not include those homozygous males that failed to produce any progeny

♂ • no obvious abnormalities in seminiferous tubules or spermatogenesis are seen in homozygous males

♂ • female fertility is normal

impaired fertilization ( J:89881 )

• at E1.0 only 38% of embryos fertilized by homozygous males had reached cell division compared to 62% for wild-type males

• the difference in fertilization rate decreased from 39% on E1.0 to 15% on E2.0 suggesting both impaired fertilization and a delay in the first cell division

• at E3.5 only 33% of embryos fertilized by homozygous males had reached the late morula or blastocyst stage compared to 78% for wild-type males