Phenotypes associated with this allele

• Allele Symbol: Tg(Camk2a-IDE)1Selk
• Allele Name: transgene insertion 1, Dennis J Selkoe
• Allele ID: MGI:3043428
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Camk2a-IDE)1Selk/0 Zbtb20^Tg(PDGFB-APPSwInd)20Lms/0	involves: C57BL/6 * DBA/2	MGI:3721976
tg2	Tg(Camk2a-IDE)1Selk/0	involves: C57BL/6	MGI:3721973

Genotype
MGI:3721976

cx1

• Allelic Composition: Tg(Camk2a-IDE)1Selk/0; Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:87150 )

• attenuated premature death at 6 months relative to Tg(PDGFB-APPSwInd)20Lms single transgenic littermates

nervous system

amyloid beta deposits ( J:87150 )

• at 6-10 months, soluble and insoluble Abeta-40 and -42 peptide levels are reduced by ~50% relative to Tg(PDGFB-APPSwInd)20Lms single transgenic mice; amyloid plaque burden is reduced by ~50%

gliosis ( J:87150 )

• microgliosis is reduced

astrocytosis ( J:87150 )

• decreased relative to Tg(PDGFB-APPSwInd)20Lms single transgenic littermates

abnormal neurite morphology ( J:87150 )

• number of dystrophic neurites is reduced relative to Tg(PDGFB-APPSwInd)20Lms single transgenic mice

homeostasis/metabolism

amyloid beta deposits ( J:87150 )

• at 6-10 months, soluble and insoluble Abeta-40 and -42 peptide levels are reduced by ~50% relative to Tg(PDGFB-APPSwInd)20Lms single transgenic mice; amyloid plaque burden is reduced by ~50%

Genotype
MGI:3721973

tg2

• Allelic Composition: Tg(Camk2a-IDE)1Selk/0
• Genetic Background: involves: C57BL/6

normal phenotype

no abnormal phenotype detected ( J:87150 )

• mice are fertile, with no overt abnormalities