Phenotypes associated with this allele

• Allele Symbol: Tg(MMTV-cre)AElee
• Allele Name: transgene insertion A, Eva YHP Lee
• Allele ID: MGI:3043429
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Trp53^tm1Elee/Trp53^tm1Elee Tg(MMTV-cre)AElee/0	involves: 129S4/SvJae * C57BL/6	MGI:3044051
cn2	Trp53^tm1Elee/Trp53^+ Tg(MMTV-cre)AElee/0	involves: 129S4/SvJae * C57BL/6	MGI:3044053

Genotype
MGI:3044051

cn1

• Allelic Composition: Trp53^tm1Elee/Trp53^tm1Elee; Tg(MMTV-cre)AElee/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:90247 )

• most common tumors were mammary tumors

• 60-80% of those with mammary tumors had multiple primary tumors

• nulliparous females developed tumors between 14 and 24 months of age, averaging 17.5 months

• multiparous females with shortened latency, develop between 11.5 and 24 months with an average of 15.5 months

increased mammary adenocarcinoma incidence ( J:90247 )

• all mammary tumors were adenocarcinomas, myoepithelial adenocarcinomas, adenosquamous carcinomas, or spindle cell tumors

• mostly poorly differentiated and invasive

• about 50% with metastasis to lung or liver

increased lymphoma incidence ( J:90247 )

• some lymphomas occur

integument

increased mammary gland tumor incidence ( J:90247 )

• most common tumors were mammary tumors

• 60-80% of those with mammary tumors had multiple primary tumors

• nulliparous females developed tumors between 14 and 24 months of age, averaging 17.5 months

• multiparous females with shortened latency, develop between 11.5 and 24 months with an average of 15.5 months

increased mammary adenocarcinoma incidence ( J:90247 )

• all mammary tumors were adenocarcinomas, myoepithelial adenocarcinomas, adenosquamous carcinomas, or spindle cell tumors

• mostly poorly differentiated and invasive

• about 50% with metastasis to lung or liver

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:90247 )

• most common tumors were mammary tumors

• 60-80% of those with mammary tumors had multiple primary tumors

• nulliparous females developed tumors between 14 and 24 months of age, averaging 17.5 months

• multiparous females with shortened latency, develop between 11.5 and 24 months with an average of 15.5 months

increased mammary adenocarcinoma incidence ( J:90247 )

• all mammary tumors were adenocarcinomas, myoepithelial adenocarcinomas, adenosquamous carcinomas, or spindle cell tumors

• mostly poorly differentiated and invasive

• about 50% with metastasis to lung or liver

Genotype
MGI:3044053

cn2

• Allelic Composition: Trp53^tm1Elee/Trp53⁺; Tg(MMTV-cre)AElee/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6

neoplasm

increased tumor latency ( J:90247 )

• latency was very long with very low penetrance