Phenotypes associated with this allele

• Allele Symbol: Neurl2^tm1Adz
• Allele Name: targeted mutation 1, Alessandro dAzzo
• Allele ID: MGI:3043523
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Neurl2^tm1Adz/Neurl2^tm1Adz	involves: 129S1/Sv * C57BL/6	MGI:3043524

Genotype
MGI:3043524

hm1

• Allelic Composition: Neurl2^tm1Adz/Neurl2^tm1Adz
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:90054 )

• from 1 - 6 months the body weight of homozygotes averaged 20% less than wild-type littermates

muscle

abnormal skeletal muscle morphology ( J:90054 )

• the striation pattern in sections from the soleus muscle of adult homozygotes is abnormal

• between 1 and 6 months of age myofibers from the soleus and quadriceps muscles display misalignment of the Z-bands frequently associated with widening of the Z-band and thinning of surrounding structures

• the frequency of myofibril branching and splitting is also increased in the soleus and quadriceps muscles between 1 and 6 months of age