Phenotypes associated with this allele

• Allele Symbol: Mchr1^tm1Ohl
• Allele Name: targeted mutation 1, Claes Ohlsson
• Allele ID: MGI:3043698
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mchr1^tm1Ohl/Mchr1^tm1Ohl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3043700

Genotype
MGI:3043700

hm1

• Allelic Composition: Mchr1^tm1Ohl/Mchr1^tm1Ohl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased compact bone mass ( J:90102 )

decreased compact bone thickness ( J:90102 )

osteoporosis ( J:90102 )

• reduction in the cortical bone mass due to decreased cortical bone thickness, while the amount of trabecular bone is unaffected

• increased serum levels of c-telopeptide, a marker of bone resorption, indicating mice have a high bone turnover osteoporosis

homeostasis/metabolism

increased circulating type I collagen C-terminal telopeptide level ( J:90102 )

• increased serum levels of c-telopeptide, a marker of bone resorption