Phenotypes associated with this allele

• Allele Symbol: Gjb2^tm1Mony
• Allele Name: targeted mutation 1, Hannah Monyer
• Allele ID: MGI:3043744
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gjb2^tm1Mony/Gjb2^tm1Mony	involves: 129S1/Sv * 129X1/SvJ	MGI:3043745

Genotype
MGI:3043745

hm1

• Allelic Composition: Gjb2^tm1Mony/Gjb2^tm1Mony
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:89907 )

• no homozygotes are obtained postnatally, indicating embryonic lethality

embryo

embryonic growth retardation ( J:89907 )

• at E13, some, but not all, mutant embryos appear developmentally retarded

growth/size/body

embryonic growth retardation ( J:89907 )

• at E13, some, but not all, mutant embryos appear developmentally retarded

decreased fetal size ( J:89907 )

• at E18, mutant fetuses appear significantly smaller than wild-type fetuses

fetal growth retardation ( J:89907 )

• by E18, homozygotes show a severe reduction in growth and development