Phenotypes associated with this allele

• Allele Symbol: Nr4a3^tm1Wnt
• Allele Name: targeted mutation 1, Astar Winoto
• Allele ID: MGI:3043761
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr4a3^tm1Wnt/Nr4a3^tm1Wnt	involves: 129S4/SvJae	MGI:3043765
ht2	Nr4a3^tm1Wnt/Nr4a3^+	involves: 129S4/SvJae	MGI:3043766

Genotype
MGI:3043765

hm1

• Allelic Composition: Nr4a3^tm1Wnt/Nr4a3^tm1Wnt
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal mesoderm accumulation in E7 Nr4a3^tm1Wnt/Nr4a3^tm1Wnt embryos

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:89944 )

• homozygous embryos die around E8.5

embryo

abnormal gastrulation ( J:89944 )

• at E6.5 - E8.5 marker expression patterns suggest that homozygous embryos have delayed formation of the anterior mesoderm

abnormal gastrulation movements ( J:89944 )

• at E7.0 mesoderm accumulates midway along the proximal distal axis in the primitive streak

• at E7.0 cells accumulate at the proximal posterior of the epiblast in homozygous embryos

abnormal embryonic tissue morphology ( J:89944 )

• at E7.5 homozygous embryos display morphological abnormalities

Genotype
MGI:3043766

ht2

• Allelic Composition: Nr4a3^tm1Wnt/Nr4a3⁺
• Genetic Background: involves: 129S4/SvJae

mortality/aging

prenatal lethality, incomplete penetrance ( J:89944 )

• fewer than expected heterozygous mice are found at birth

embryo

embryonic growth retardation ( J:89944 )

• at E8.5 some heterozygous embryos resemble E7.75 embryos

abnormal embryonic tissue morphology ( J:89944 )

• at E8.5 these delayed embryos also exhibit abnormal morphology

growth/size/body

embryonic growth retardation ( J:89944 )

• at E8.5 some heterozygous embryos resemble E7.75 embryos