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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tfr2tm1.1Nsub
targeted mutation 1.1, V Nathan Subramaniam
MGI:3043773
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tfr2tm1.1Nsub/Tfr2tm1.1Nsub involves: 129T2/SvEms MGI:4458423
hm2
 		Tfr2tm1.1Nsub/Tfr2tm1.1Nsub involves: 129T2/SvEms * C57BL/6 MGI:3718692


Genotype
MGI:4458423
hm1
Allelic
Composition		 Tfr2tm1.1Nsub/Tfr2tm1.1Nsub
Genetic
Background		 involves: 129T2/SvEms
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfr2tm1.1Nsub mutation (0 available); any Tfr2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased spleen iron level ( J:160785 )
• mainly in the white pulp from 11 months of age

homeostasis/metabolism
increased spleen iron level ( J:160785 )
• mainly in the white pulp from 11 months of age
increased liver iron level ( J:160785 )
• at P14 and further at 22 and 52 weeks

liver/biliary system
increased liver iron level ( J:160785 )
• at P14 and further at 22 and 52 weeks

immune system
increased spleen iron level ( J:160785 )
• mainly in the white pulp from 11 months of age




Genotype
MGI:3718692
hm2
Allelic
Composition		 Tfr2tm1.1Nsub/Tfr2tm1.1Nsub
Genetic
Background		 involves: 129T2/SvEms * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfr2tm1.1Nsub mutation (0 available); any Tfr2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased spleen iron level ( J:114330 )
• significantly decreased
increased circulating iron level ( J:114330 )
• at 10 weeks, mice have elevated transferrin saturation (83.7% compared to 36.7% in wild-type mice)
increased liver iron level ( J:114330 )
• hepatic iron concentration is 5-fold higher (1023 compared to 188.8 ug/g in wild-type mice)
hemochromatosis ( J:114330 )
• the iron staining pattern in hepatocytes is similar to that seen in patients with Tfr2 associated hemochoromatosis

hematopoietic system
decreased spleen iron level ( J:114330 )
• significantly decreased

immune system
decreased spleen iron level ( J:114330 )
• significantly decreased

liver/biliary system
increased liver iron level ( J:114330 )
• hepatic iron concentration is 5-fold higher (1023 compared to 188.8 ug/g in wild-type mice)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory