Phenotypes associated with this allele

• Allele Symbol: Pdpk1^tm1Ejm
• Allele Name: targeted mutation 1, Edward J McManus
• Allele ID: MGI:3043781
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdpk1^tm1Ejm/Pdpk1^tm1Ejm	involves: 129P2/OlaHsd * BALB/c	MGI:3043789

Genotype
MGI:3043789

hm1

• Allelic Composition: Pdpk1^tm1Ejm/Pdpk1^tm1Ejm
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:90081 )

• death around E11, putatively due to blood vessel defects in the head and impaired placental development

cardiovascular system

abnormal vasculogenesis ( J:90081 )

• absence of visible blood vessels in the extraembryonic tissue at E10.5

embryo

abnormal first pharyngeal arch morphology ( J:90081 )

• the maxillary portion of the first branchial arch partially covers the eye

abnormal embryo development ( J:90081 )

• embryos show first signs of growth retardation and the development of blood islands from around the otic vesicle through to the forebrain by E8.5

decreased embryo size ( J:90081 )

• first evident at E8.5

abnormal extraembryonic tissue morphology ( J:90081 )

• impaired extraembryonic vasculogenesis

abnormal placenta development ( J:90081 )

growth/size/body

decreased embryo size ( J:90081 )

• first evident at E8.5

nervous system

abnormal brain development ( J:90081 )

abnormal forebrain morphology ( J:90081 )

• abnormal shape

decreased forebrain size ( J:90081 )

absent dorsal root ganglion ( J:90081 )

• absent at E9.5

craniofacial

abnormal first pharyngeal arch morphology ( J:90081 )

• the maxillary portion of the first branchial arch partially covers the eye