Phenotypes associated with this allele

• Allele Symbol: Pdpk1^tm2Ejm
• Allele Name: targeted mutation 2, Edward J McManus
• Allele ID: MGI:3043785
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdpk1^tm2Ejm/Pdpk1^tm2Ejm	involves: 129P2/OlaHsd * BALB/c	MGI:3043814
ht2	Pdpk1^tm2Ejm/Pdpk1^+	involves: 129P2/OlaHsd * BALB/c	MGI:3043816

Genotype
MGI:3043814

hm1

• Allelic Composition: Pdpk1^tm2Ejm/Pdpk1^tm2Ejm
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:90081 )

• death around E12

cardiovascular system

cardiovascular system phenotype ( J:90081 )

N • no defects in blood vessel formation

embryo

embryo phenotype ( J:90081 )

N • normal placental development

abnormal developmental patterning ( J:90081 )

• around E9.5, some embryos exhibited a twisting of the posterior portion of the body axis around the dorso-ventral and left-right axes

• the twisting only occurs only at the thoracic somites and once the twisting has occurred, the body axis continues to grow along the new line without further twisting

embryonic growth retardation ( J:90081 )

• embryonic growth retardation was first evident at E8.5 in some mice and continued through E11.5 when some embryos were retarded by at least 1 day

growth/size/body

embryonic growth retardation ( J:90081 )

• embryonic growth retardation was first evident at E8.5 in some mice and continued through E11.5 when some embryos were retarded by at least 1 day

nervous system

nervous system phenotype ( J:90081 )

N • dorsal root ganglia were observed

abnormal brain development ( J:90081 )

decreased forebrain size ( J:90081 )

• reduced in size

• first evident at E8.5-E9.5, but more apparent at E10.5 and E11.5

• the branchial arch was not covering the eye

Genotype
MGI:3043816

ht2

• Allelic Composition: Pdpk1^tm2Ejm/Pdpk1⁺
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

mortality/aging

prenatal lethality, incomplete penetrance ( J:90081 )

• incomplete penetrance with approximately 50% dying after E11.5