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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdk5tm2Kul
targeted mutation 2, Ashok B Kulkarni
MGI:3043819
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cdk5tm2Kul/Cdk5tm2Kul involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3043820
cn2
 		Cdk5tm2Kul/Cdk5tm2Kul
Tg(Nefh-cre)12Kul/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N MGI:3043832


Genotype
MGI:3043820
hm1
Allelic
Composition		 Cdk5tm2Kul/Cdk5tm2Kul
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk5tm2Kul mutation (0 available); any Cdk5 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3043832
cn2
Allelic
Composition		 Cdk5tm2Kul/Cdk5tm2Kul
Tg(Nefh-cre)12Kul/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk5tm2Kul mutation (0 available); any Cdk5 mutation (17 available)
Tg(Nefh-cre)12Kul mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain development ( J:89561 )
• 25% exhibited neuronal migration defects in the cerebral cortex; restricted to later-generated cortical neurons
• immunostaining of ectopic neurons indicated that the defects were cell-autonomous
abnormal hippocampus development ( J:89561 )
• disorganization of the CA3 region
• the CA1 region was unaffected
abnormal cerebellum development ( J:89561 )
• many granule cells were arrested in the molecular layer
• in some cases, defects in Purkinje cell migration were observed
abnormal olfactory bulb development ( J:89561 )
• disorganized mitral cell layer
• reduced granule cell density relative to controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory