Analysis Tools
hematopoietic system
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• splenomegaly in aged mice which is further enhanced by G-CSF injection
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• hematopoiesis is perturbed after 17 weeks of age
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• erythropoiesis is diminished in the bone marrow but increases in the spleen
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• increased myelopoiesis in the bone marrow
• cells from the neutrophilic granulocyte lineage, when stimulated with G-CSF, show an increase in cloning frequency, survival, and proliferative capacity
• myeloid cells are hyperresponsive to G-CSF and exhibit increased proliferation and survival upon stimulation
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• abnormalities in G-CSF-induced emergency granulocyte production; mutants injected with G-CSG exhibit enhanced neutrophilia, progenitor cell mobilization, and splenomegaly, and develop inflammatory neutrophil infiltration into multiple tissues and hind-leg paresis
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• splenomegaly with prominent extramedullary hematopoiesis
• splenomegaly is enhanced by injection with G-CSF
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• mutants develop neutrophilia in adulthood
• neutrophilia is enhanced by injection with granulocyte colony-stimulating factor (G-CSF)
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• hematopoietic progenitors show enhanced G-CSF and IL-6 induced colony formation
• G-CSF responsive progenitor cells generate higher proportions of macrophage and granulocyte-macrophage colonies than control cells
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immune system
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• splenomegaly in aged mice which is further enhanced by G-CSF injection
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• increased myelopoiesis in the bone marrow
• cells from the neutrophilic granulocyte lineage, when stimulated with G-CSF, show an increase in cloning frequency, survival, and proliferative capacity
• myeloid cells are hyperresponsive to G-CSF and exhibit increased proliferation and survival upon stimulation
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• abnormalities in G-CSF-induced emergency granulocyte production; mutants injected with G-CSG exhibit enhanced neutrophilia, progenitor cell mobilization, and splenomegaly, and develop inflammatory neutrophil infiltration into multiple tissues and hind-leg paresis
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• mutants develop neutrophilia in adulthood
• neutrophilia is enhanced by injection with granulocyte colony-stimulating factor (G-CSF)
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• mutants develop an inflammatory disease after 17 weeks of age characterized by inflammation in the pleural and peritoneal cavities, neutrophil leukocytosis, and infiltration of liver and lungs by hematopoietic cells from multiple lineages
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• infiltration of liver by hematopoietic cells from multiple lineages
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• infiltration of the lungs by hematopoietic cells from multiple lineages
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digestive/alimentary system
liver/biliary system
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• infiltration of liver by hematopoietic cells from multiple lineages
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respiratory system
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• infiltration of the lungs by hematopoietic cells from multiple lineages
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cellular
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• abnormalities in G-CSF-induced emergency granulocyte production; mutants injected with G-CSG exhibit enhanced neutrophilia, progenitor cell mobilization, and splenomegaly, and develop inflammatory neutrophil infiltration into multiple tissues and hind-leg paresis
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growth/size/body
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• splenomegaly in aged mice which is further enhanced by G-CSF injection
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