All Phenotypes Mlxipl<tm1Kuy> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mlxipl^tm1Kuy/Mlxipl^tm1Kuy	B6.129S6-Mlxipl^tm1Kuy/J	MGI:6297092
hm2	Mlxipl^tm1Kuy/Mlxipl^tm1Kuy	involves: 129S6/SvEvTac * C57BL/6J	MGI:3043880

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

weight loss ( J:273754 )

• mice exhibit a significant weight loss when fed a high fructose diet (60% fructose, 10% starch), showing a 20% reduction in body weight after 5 days on the diet

• body weight recovers within 6 days after switching back to the control diet

digestive/alimentary system

diarrhea ( J:273754 )

• mice fed a high fructose diet develop severe diarrhea

increased cecum weight ( J:273754 )

• cecum weight is increased in mice fed a high fructose diet

distended cecum ( J:273754 )

• on day 3 of a high fructose diet, mice exhibit enlarged ceca that contains fluid

• by day 5 and through day 7 of the high fructose diet, mice exhibit enlarged, red intestines and extremely distended ceca that contain both fluid and gas

increased colon length ( J:273754 )

• colon length is increased in mice fed a high fructose diet

decreased defecation amount ( J:273754 )

• fecal pellets are decreased in high fructose fed mice

abnormal intestinal fructose absorption ( J:273754 )

• fructose levels in feces are 2-fold higher in mice fed a high fructose diet, indicating development of fructose intolerance

• plasma alanine transaminase, aspartate transaminase, and lactate dehydrogenase, indicators of liver injury, are not increased in mutant mice fed a high fructose diet unlike in wild-type mice that show an increase in their levels, indicating resistance to liver damage by high fructose diet due to impaired fructose absorption

• on the high fructose diet, lactate levels in the intestine are not increased as in wild-type mice and lactate levels in the liver are decreased in mutants indicating impaired fructose conversion into lactate in the intestine but not the liver

behavior/neurological

decreased food intake ( J:273754 )

• average daily food intake is lower in mice fed a high fructose diet

• food intake is decreased by more than 50% within 1-2 days after starting the high fructose diet and increases right after switching back to the control diet

homeostasis/metabolism

decreased circulating glucose level ( J:273754 )

• males exhibit a lower blood glucose levels when fed a high fructose diet

increased circulating glucose level ( J:273754 )

• females exhibit a slight increase in blood glucose levels when fed a high fructose diet

decreased circulating cholesterol level ( J:273754 )

• plasma cholesterol levels are decreased in mutant mice on both a control diet and the high fructose diet

decreased circulating triglyceride level ( J:273754 )

• plasma triglyceride levels are decreased in mutant mice on both a control diet and the high fructose diet

decreased body temperature ( J:273754 )

• mice exhibit lower body temperature when fed a high fructose diet

decreased liver triglyceride level ( J:273754 )

• liver triglyceride levels are decreased in mutant mice on both a control diet and the high fructose diet

liver/biliary system

decreased liver triglyceride level ( J:273754 )

• liver triglyceride levels are decreased in mutant mice on both a control diet and the high fructose diet

mortality/aging

premature death ( J:273754 )

• mice fed a high fructose diet become moribund in 2 weeks

• mice younger than 5 weeks that are fed the high fructose diet become moribund within a few days

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
irritable bowel syndrome		DOID:9778		J:273754

Allelic Composition	Mlxipl^tm1Kuy/Mlxipl^tm1Kuy
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlxipl^tm1Kuy mutation (1 available); any Mlxipl mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:89865 )

• on a 70% sucrose diet homozygous mice die in less than 1 week

• on a high-fructose diet homozygous mice die within a few days

• on a standard chow diet homozygous mice have a normal life span

cellular

asthenozoospermia ( J:324060 )

immotile sperm ( J:324060 )

growth/size/body

increased liver weight ( J:89865 )

• on a high starch diet liver weight are about 40% greater in homozygous mice compared to wild-type mice probably as a result of increased glycogen stores in homozygous mice

adipose tissue

decreased brown adipose tissue amount ( J:89865 )

• on a standard diet homozygous mice have lower brown fat weights

decreased white adipose tissue amount ( J:89865 )

decreased epididymal fat pad weight ( J:89865 )

• on a standard diet homozygous mice have lower epididymal fat weights

homeostasis/metabolism

decreased body temperature ( J:89865 )

• on a 70% sucrose diet homozygous mice develop hypothermia

abnormal glucose homeostasis ( J:89865 )

increased circulating glucose level ( J:89865 )

• plasma glucose levels are somewhat elevated

increased circulating insulin level ( J:89865 )

• plasma insulin levels are somewhat elevated

• on a high-starch diet plasma insulin levels increase significantly compared to homozygous mice on a standard diet or wild-type mice on either diet

increased liver glycogen level ( J:89865 )

• liver glycogen levels are elevated but muscle glycogen levels are not elevated

• liver glycogen levels are elevated further on a high-starch diet

insulin resistance ( J:89865 )

• on a high-starch diet homozygous mice are moderately insulin resistant

abnormal lipid homeostasis ( J:89865 )

decreased circulating cholesterol level ( J:89865 )

• on a high starch diet plasma cholesterol is significantly lower compared to wild-type mice on the same diet

decreased fatty acids level ( J:89865 )

• hepatic fatty acid synthesis rates are 65% lower in homozygous mice

decreased circulating free fatty acids level ( J:89865 )

• on either a standard or high-starch diet plasma free fatty acid levels are about 50% that in wild-type mice on the same diet

• on a 70% sucrose diet free fatty acid levels decline further in homozygous mice

reproductive system

asthenozoospermia ( J:324060 )

immotile sperm ( J:324060 )

male infertility ( J:324060 )

liver/biliary system

increased liver weight ( J:89865 )

• on a high starch diet liver weight are about 40% greater in homozygous mice compared to wild-type mice probably as a result of increased glycogen stores in homozygous mice

increased liver glycogen level ( J:89865 )

• liver glycogen levels are elevated but muscle glycogen levels are not elevated

• liver glycogen levels are elevated further on a high-starch diet

abnormal liver physiology ( J:89865 )

• hepatic glucose levels are increased

• hepatic pyruvate/phosphoenolpyruvate ratio is decreased indicating inhibition of hepatic glycolysis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24