All Phenotypes Mutyh<tm1Jhmi> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mutyh^tm1Jhmi/Mutyh^tm1Jhmi	involves: 129X1/SvJ * C57BL/6J	MGI:3043934
cx2	Mutyh^tm1Jhmi/Mutyh^tm1Jhmi Ogg1^tm1Tld/Ogg1^tm1Tld	involves: 129 * C57BL/6J	MGI:3043935
cx3	Msh2^tm1Mak/Msh2^tm1Mak Mutyh^tm1Jhmi/Mutyh^tm1Jhmi Ogg1^tm1Tld/Ogg1^tm1Tld	involves: 129 * C57BL/6J	MGI:3043936
cx4	Msh2^tm1Mak/Msh2⁺ Mutyh^tm1Jhmi/Mutyh^tm1Jhmi Ogg1^tm1Tld/Ogg1^tm1Tld	involves: 129 * C57BL/6J	MGI:3043953

Allelic Composition	Mutyh^tm1Jhmi/Mutyh^tm1Jhmi
Genetic Background	involves: 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mutyh^tm1Jhmi mutation (0 available); any Mutyh mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:89742 )

N	• mice do not show increased tumor incidence relative to wild-type through 17 months of age

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:89742 )

• the 50% survival age is 10.3 months

neoplasm

increased tumor incidence ( J:89742 )

• 65.7% of mice develop tumors, predominantly lymphoma (37.1%), ovarian tumors (34.8%), and lung adenomas (31.4%)

• 75% of lung tumors have a G to T mutation in codon 12 of Kras2

increased ovary tumor incidence ( J:89742 )

• 34.8% of mutants develop ovarian tumors after 12 months of age

• 4 of 5 ovarian tumors are bilateral

increased hemangioma incidence ( J:89742 )

• most ovarian tumors are hemangiomas which can result in lethal hemorrhaging

increased lymphoma incidence ( J:89742 )

• observe in 37.1% of mice, with extensive lymphoma burdens in most organs such as the lung, heart, liver, spleen, kidneys, and lymph nodes

increased lung tumor incidence ( J:89742 )

• 31.4% of mutants develop lung tumors after 12 months of age

• 78.6% of older mutants that live more than 12 months develop lung tumors

• lung tumors are solitary and white nodules with a 1-10 mm diameter

increased lung adenoma incidence ( J:89742 )

• most lung tumors are adenomas, seen in 31.4% of mutants

endocrine/exocrine glands

increased ovary tumor incidence ( J:89742 )

• 34.8% of mutants develop ovarian tumors after 12 months of age

• 4 of 5 ovarian tumors are bilateral

reproductive system

increased ovary tumor incidence ( J:89742 )

• 34.8% of mutants develop ovarian tumors after 12 months of age

• 4 of 5 ovarian tumors are bilateral

respiratory system

increased lung tumor incidence ( J:89742 )

• 31.4% of mutants develop lung tumors after 12 months of age

• 78.6% of older mutants that live more than 12 months develop lung tumors

• lung tumors are solitary and white nodules with a 1-10 mm diameter

increased lung adenoma incidence ( J:89742 )

• most lung tumors are adenomas, seen in 31.4% of mutants

Allelic Composition	Msh2^tm1Mak/Msh2^tm1Mak Mutyh^tm1Jhmi/Mutyh^tm1Jhmi Ogg1^tm1Tld/Ogg1^tm1Tld
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2^tm1Mak mutation (1 available); any Msh2 mutation (95 available)
Mutyh^tm1Jhmi mutation (0 available); any Mutyh mutation (36 available)
Ogg1^tm1Tld mutation (0 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:89742 )

• the 50% survival age is 4.3 months and all mutants die within 10.3 months

neoplasm

increased tumor incidence ( J:89742 )

• 86.7% of mice develop tumors, predominantly lymphoma (76.7%) with some incidence of lung adenoma (10%)

increased lung adenoma incidence ( J:89742 )

• observe in 10% of mice

increased lymphoma incidence ( J:89742 )

• observe in 76.7% of mice

respiratory system

increased lung adenoma incidence ( J:89742 )

• observe in 10% of mice

Allelic Composition	Msh2^tm1Mak/Msh2⁺ Mutyh^tm1Jhmi/Mutyh^tm1Jhmi Ogg1^tm1Tld/Ogg1^tm1Tld
Genetic Background	involves: 129 * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:89742 )

• the 50% survival age is around 10 months

neoplasm

increased tumor incidence ( J:89742 )

• 76.9% of mice develop tumors, including ovarian tumors (57.6%), lung adenomas (35.9%), lung adenocarcinoma (61.3%), lymphoma (26.9%)

increased ovary tumor incidence ( J:89742 )

• in 57.6% of mice, with the earliest onset at 5 months of age

increased lung adenoma incidence ( J:89742 )

• observe in 35.9% of mice

increased lymphoma incidence ( J:89742 )

• observe in 26.9% of mice

increased lung adenocarcinoma incidence ( J:89742 )

• 61.3% of mutants develop lung adenocarcinomas after 10.6 months of age

respiratory system

increased lung adenoma incidence ( J:89742 )

• observe in 35.9% of mice

increased lung adenocarcinoma incidence ( J:89742 )

• 61.3% of mutants develop lung adenocarcinomas after 10.6 months of age

endocrine/exocrine glands

increased ovary tumor incidence ( J:89742 )

• in 57.6% of mice, with the earliest onset at 5 months of age

reproductive system

increased ovary tumor incidence ( J:89742 )

• in 57.6% of mice, with the earliest onset at 5 months of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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