All Phenotypes Gja10<tm1Kwi> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gja10^tm1Kwi/Gja10^tm1Kwi	involves: 129P2/OlaHsd * C57BL/6	MGI:3043948
ht2	Gja10^tm1Kwi/Gja10⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3783582

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina horizontal cell morphology ( J:111597 , J:133140 )

• horizontal cell axon terminals were accompanied by occasional thick globular tangles (J:111597)

• horizontal cells coupling is reduced by 99% as determined by passage of dye from one horizontal cell to others (J:111597)

• horizontal cells have defects in coupling to each other as determined by passage of dye from one horizontal cell to others (J:133140)

abnormal eye electrophysiology ( J:111597 )

• the dark resting potential of horizontal cells is significantly more depolarized than wild-type controls

• the maximal full-field response amplitudes of horizontal cells is significantly reduced

• the mean input resistance of horizontal cells is 27% lower than in wild-type mice

nervous system

abnormal retina horizontal cell morphology ( J:111597 , J:133140 )

• horizontal cell axon terminals were accompanied by occasional thick globular tangles (J:111597)

• horizontal cells coupling is reduced by 99% as determined by passage of dye from one horizontal cell to others (J:111597)

• horizontal cells have defects in coupling to each other as determined by passage of dye from one horizontal cell to others (J:133140)

Allelic Composition	Gja10^tm1Kwi/Gja10⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja10^tm1Kwi mutation (1 available); any Gja10 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina horizontal cell morphology ( J:111597 )

abnormal eye electrophysiology ( J:111597 )

• the dark resting potential of horizontal cells is significantly more depolarized than wild-type controls but is not as depolarized as in homozygotes

• the maximal full-field response amplitudes of horizontal cells is significantly reduced but not to the extent that occurs in homozygotes

nervous system

abnormal retina horizontal cell morphology ( J:111597 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24