All Phenotypes Gja10<tm1Kwi> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gja10^tm1Kwi/Gja10^tm1Kwi	involves: 129P2/OlaHsd * C57BL/6	MGI:3043948
ht2	Gja10^tm1Kwi/Gja10⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3783582

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina horizontal cell morphology ( J:111597 , J:133140 )

• horizontal cell axon terminals were accompanied by occasional thick globular tangles (J:111597)

• horizontal cells coupling is reduced by 99% as determined by passage of dye from one horizontal cell to others (J:111597)

• horizontal cells have defects in coupling to each other as determined by passage of dye from one horizontal cell to others (J:133140)

abnormal eye electrophysiology ( J:111597 )

• the dark resting potential of horizontal cells is significantly more depolarized than wild-type controls

• the maximal full-field response amplitudes of horizontal cells is significantly reduced

• the mean input resistance of horizontal cells is 27% lower than in wild-type mice

nervous system

abnormal retina horizontal cell morphology ( J:111597 , J:133140 )

• horizontal cell axon terminals were accompanied by occasional thick globular tangles (J:111597)

• horizontal cells coupling is reduced by 99% as determined by passage of dye from one horizontal cell to others (J:111597)

• horizontal cells have defects in coupling to each other as determined by passage of dye from one horizontal cell to others (J:133140)

Allelic Composition	Gja10^tm1Kwi/Gja10⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja10^tm1Kwi mutation (1 available); any Gja10 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina horizontal cell morphology ( J:111597 )

abnormal eye electrophysiology ( J:111597 )

• the dark resting potential of horizontal cells is significantly more depolarized than wild-type controls but is not as depolarized as in homozygotes

• the maximal full-field response amplitudes of horizontal cells is significantly reduced but not to the extent that occurs in homozygotes

nervous system

abnormal retina horizontal cell morphology ( J:111597 )

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