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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sqstm1tm1Jmos
targeted mutation 1, Jorge Moscat
MGI:3043976
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sqstm1tm1Jmos/Sqstm1tm1Jmos involves: 129S1/Sv * 129X1/SvJ MGI:5487463
hm2
 		Sqstm1tm1Jmos/Sqstm1tm1Jmos involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3043977


Genotype
MGI:5487463
hm1
Allelic
Composition		 Sqstm1tm1Jmos/Sqstm1tm1Jmos
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sqstm1tm1Jmos mutation (0 available); any Sqstm1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal aerobic respiration ( J:194291 )
• brown adipose tissue primary cells fail to exhibit increased oxygen consumption in response to isoproterenol treatment unlike wild-type cells




Genotype
MGI:3043977
hm2
Allelic
Composition		 Sqstm1tm1Jmos/Sqstm1tm1Jmos
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sqstm1tm1Jmos mutation (0 available); any Sqstm1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoclast differentiation ( J:90010 )
• while basal osteoclastogenesis was normal, osteoclastogenesis was impaired relative to controls in response to an osteoclastogenic stimulus (the calcitropic hormone PTHrP)
• bone marrow-derived macrophages do not exhibit a robust osteoclastogenic response to M-CSF and RANK-L as seen in wild-type cells
decreased osteoclast cell number ( J:90010 )
• in response to an osteoclastogenic stimulus, PTHrP, mutants exhibit fewer osteoclasts

immune system
abnormal osteoclast differentiation ( J:90010 )
• while basal osteoclastogenesis was normal, osteoclastogenesis was impaired relative to controls in response to an osteoclastogenic stimulus (the calcitropic hormone PTHrP)
• bone marrow-derived macrophages do not exhibit a robust osteoclastogenic response to M-CSF and RANK-L as seen in wild-type cells
decreased osteoclast cell number ( J:90010 )
• in response to an osteoclastogenic stimulus, PTHrP, mutants exhibit fewer osteoclasts
decreased interleukin-6 secretion ( J:90010 )
• IL-6 production in response to PTHrP injection is reduced in mutants

hematopoietic system
abnormal osteoclast differentiation ( J:90010 )
• while basal osteoclastogenesis was normal, osteoclastogenesis was impaired relative to controls in response to an osteoclastogenic stimulus (the calcitropic hormone PTHrP)
• bone marrow-derived macrophages do not exhibit a robust osteoclastogenic response to M-CSF and RANK-L as seen in wild-type cells
decreased osteoclast cell number ( J:90010 )
• in response to an osteoclastogenic stimulus, PTHrP, mutants exhibit fewer osteoclasts

cellular
abnormal osteoclast differentiation ( J:90010 )
• while basal osteoclastogenesis was normal, osteoclastogenesis was impaired relative to controls in response to an osteoclastogenic stimulus (the calcitropic hormone PTHrP)
• bone marrow-derived macrophages do not exhibit a robust osteoclastogenic response to M-CSF and RANK-L as seen in wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory