Phenotypes associated with this allele

• Allele Symbol: Il1rl1^tm1Brl
• Allele Name: targeted mutation 1, RCC, Ltd
• Allele ID: MGI:3043989
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il1rl1^tm1Brl/Il1rl1^tm1Brl	involves: 129S/SvEv * C57BL/6	MGI:3718678

Genotype
MGI:3718678

hm1

• Allelic Composition: Il1rl1^tm1Brl/Il1rl1^tm1Brl
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased eosinophil cell number ( J:63507 )

• following infection with N. brasiliensis, eosinophil numbers in peripheral blood increase to 12 to 15% of total blood cells

decreased interleukin-5 secretion ( J:63507 )

• following infection with N. brasiliensis, IL-5 production is decreased

abnormal response to infection ( J:63507 )

• following infection with N. brasiliensis, no CD4+/T1+ lymphocytes are detected

• 12 days following infection with N. brasiliensis, IL-5+ CD4 T cells are slightly decreased and IL-5 production is decreased

• following infection with N. brasiliensis, eosinophil numbers in peripheral blood increase to 12 to 15% of total blood cells

• however, the number of parasitic eggs following infection is equivalent to in wild-type mice

hematopoietic system

increased eosinophil cell number ( J:63507 )

• following infection with N. brasiliensis, eosinophil numbers in peripheral blood increase to 12 to 15% of total blood cells