Phenotypes associated with this allele

• Allele Symbol: H2-T23^tm1Cant
• Allele Name: targeted mutation 1, Harvey Cantor
• Allele ID: MGI:3044027
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2-T23^tm1Cant/H2-T23^tm1Cant	involves: 129S6/SvEvTac * C57BL/6	MGI:3714861

Genotype
MGI:3714861

hm1

• Allelic Composition: H2-T23^tm1Cant/H2-T23^tm1Cant
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD4-positive, alpha-beta T cell physiology ( J:123555 , J:142087 )

• survival of CD4+ lymphocytes is substantially reduced (J:123555)

• four fold more activated CD4 T cells are susceptible to natural killer cell lysis in vitro (J:142087)

• CD4 T cells fail to proliferate when transferred into an immunodeficient host (J:142087)

abnormal memory T cell physiology ( J:123555 )

• lack of antigen stimulated memory activity in CD4+ cells

increased susceptibility to experimental autoimmune encephalomyelitis ( J:89808 )

increased susceptibility to bacterial infection ( J:89808 )

• the number of Vbeta3+ CD4 T cell does not decrease following super antigen staphylococcal enterotoxin A (SEA) infection

increased susceptibility to Herpesvirales infection ( J:89808 )

• following herpes simplex virus infection, mice develop herpes simplex keratitis where as controls do not

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:89808 )

• when exposed to an MHC class II peptide mice have an inhibited CD4 response

hematopoietic system

abnormal CD4-positive, alpha-beta T cell physiology ( J:123555 , J:142087 )

• survival of CD4+ lymphocytes is substantially reduced (J:123555)

• four fold more activated CD4 T cells are susceptible to natural killer cell lysis in vitro (J:142087)

• CD4 T cells fail to proliferate when transferred into an immunodeficient host (J:142087)

abnormal memory T cell physiology ( J:123555 )

• lack of antigen stimulated memory activity in CD4+ cells