Analysis Tools
adipose tissue
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• homozygous mice on a high fat diet have significantly increased body fat unlike wild-type mice
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• female mutants on a high fat diet display a significant increase in percent body fat compared to female wild-type littermates
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behavior/neurological
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• male homozygous mice display a significant preference for amphetamines at lower concentrations compared to their male wild-type littermates
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• male homozygous mice display increased activity during the first 5 minutes in a novel environment compared to male wild-type littermates
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• only male mutants had a detectable increase in caloric consumption on a high fat diet
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hyperactivity
(
J:43791
)
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• male homozygous mice display a greater increase in activity with low doses of cocaine compared to male wild-type littermates
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growth/size/body
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• male mutants on a high fat diet display a significant increase in water content compared to male wild-type littermates
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• male mutants on a high fat diet have a significant increase in body weight compared to male wild-type littermates or male mutants on a regular diet
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homeostasis/metabolism
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• on a high fat diet plasma leptin is significantly increased in male mutants but not in their male wild-type littermates
• plasma leptin is increased on both the normal chow and high fat diets in female mutants compared to female wild-type littermates
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