All Phenotypes Tfec<tm1Est> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tfec^tm1Est
targeted mutation 1, Eirikur Steingrimsson
MGI:3044120

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tfec^tm1Est/Tfec^tm1Est	either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)	MGI:3044233
cx2	Mitf^Mi-wh/Mitf^Mi-wh Tfec^tm1Est/Tfec^tm1Est	either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)	MGI:3044429
cx3	Mitf^Mi-wh/Mitf^Mi-wh Tfe3^tm1Est/Tfe3^tm1Est Tfec^tm1Est/Tfec^tm1Est	either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)	MGI:4455023
cx4	Mitf^Mi/Mitf^Mi Tfec^tm1Est/Tfec^tm1Est	either: (involves: 129/Sv * 129S1/Sv * C57BL/6J) or (involves: 129S1/Sv * C57BL/6J)	MGI:4455021
cx5	Tfe3^tm1Est/Tfe3^tm1Est Tfec^tm1Est/Tfec^tm1Est	either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)	MGI:3044234
cx6	Tfeb^tm1Est/Tfeb⁺ Tfec^tm1Est/Tfec^tm1Est	either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)	MGI:4455031

Allelic Composition	Tfec^tm1Est/Tfec^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfec^tm1Est mutation (0 available); any Tfec mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:89821 )

• mice were indistinguishable from their wild-type littermates; exhibiting normal eyes, pigment, mast cells, osteoclasts and placentas

Allelic Composition	Mitf^Mi-wh/Mitf^Mi-wh Tfec^tm1Est/Tfec^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)
Tfec^tm1Est mutation (0 available); any Tfec mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:89821 )

skeleton

skeleton phenotype ( J:89821 )

N	• osteopetrosis is not observed amd bone development appears normal

vision/eye

microphthalmia ( J:89821 )

integument

absent coat pigmentation ( J:89821 )

Allelic Composition	Mitf^Mi-wh/Mitf^Mi-wh Tfe3^tm1Est/Tfe3^tm1Est Tfec^tm1Est/Tfec^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)
Tfe3^tm1Est mutation (1 available); any Tfe3 mutation (23 available)
Tfec^tm1Est mutation (0 available); any Tfec mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:89821 )

• white coat

skeleton

osteopetrosis ( J:89821 )

• mice develop osteopetrosis similar to that observed in double Mitf^Mi-wh and Tcfe3^tm1Est mutants

vision/eye

microphthalmia ( J:89821 )

integument

absent coat pigmentation ( J:89821 )

• white coat

Allelic Composition	Mitf^Mi/Mitf^Mi Tfec^tm1Est/Tfec^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv * C57BL/6J) or (involves: 129S1/Sv * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi mutation (3 available); any Mitf mutation (74 available)
Tfec^tm1Est mutation (0 available); any Tfec mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:89821 )

• white coat

skeleton

osteopetrosis ( J:89821 )

vision/eye

microphthalmia ( J:89821 )

integument

absent coat pigmentation ( J:89821 )

• white coat

Allelic Composition	Tfe3^tm1Est/Tfe3^tm1Est Tfec^tm1Est/Tfec^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfe3^tm1Est mutation (1 available); any Tfe3 mutation (23 available)
Tfec^tm1Est mutation (0 available); any Tfec mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:89821 )

• mice were indistinguishable from their wild-type littermates; exhibiting normal eyes, pigment, mast cells, osteoclasts and placentas

Allelic Composition	Tfeb^tm1Est/Tfeb⁺ Tfec^tm1Est/Tfec^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfeb^tm1Est mutation (0 available); any Tfeb mutation (46 available)
Tfec^tm1Est mutation (0 available); any Tfec mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:89821 )

• mice exhibit normal eyes, pigment, mast cells, and osteoclasts

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