All Phenotypes Hsf1<tm1Anak> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hsf1^tm1Anak
targeted mutation 1, Akira Nakai
MGI:3044161

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsf1^tm1Anak/Hsf1^tm1Anak	involves: C57BL/6 * CBA * ICR	MGI:3044359
hm2	Hsf1^tm1Anak/Hsf1^tm1Anak	involves: ICR	MGI:3057291
cx3	Hsf1^tm1Anak/Hsf1^tm1Anak Tg(ACTB-HSF1)1Anak/?	involves: C57BL/6 * CBA * ICR	MGI:3044360
cx4	Hsf1^tm1Anak/Hsf1^tm1Anak Hsf4^tm1Anak/Hsf4^tm1Anak	involves: C57BL/6 * CBA * ICR	MGI:3057290

Allelic Composition	Hsf1^tm1Anak/Hsf1^tm1Anak
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1^tm1Anak mutation (1 available); any Hsf1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:89846 )

N	• homozygous males are fertile with testes of normal weight and histologically normal as well

abnormal spermatogenesis ( J:89846 )

• apoptosis in seminiferous tubules of heat shocked testes was considerably reduced as compared to controls

• few late pachytene spermatocytes die as a result of heat stress

Allelic Composition	Hsf1^tm1Anak/Hsf1^tm1Anak
Genetic Background	involves: ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1^tm1Anak mutation (1 available); any Hsf1 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:93301 )

N	• no cataracts are seen and lens epithelial cell morphology is normal

Allelic Composition	Hsf1^tm1Anak/Hsf1^tm1Anak Tg(ACTB-HSF1)1Anak/?
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1^tm1Anak mutation (1 available); any Hsf1 mutation (25 available)
Tg(ACTB-HSF1)1Anak mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:89846 )

• diameter of seminiferous tubules is larger than in mice expressing endogenous Hsf1 as well as the transgene

decreased testis weight ( J:89846 )

• testis weight is low compared to normal controls but greater than in mice expressing endogenous Hsf1 as well as the transgene

reproductive system

reproductive system phenotype ( J:89846 )

N	• spermatogenesis is normal

abnormal seminiferous tubule morphology ( J:89846 )

• diameter of seminiferous tubules is larger than in mice expressing endogenous Hsf1 as well as the transgene

decreased testis weight ( J:89846 )

• testis weight is low compared to normal controls but greater than in mice expressing endogenous Hsf1 as well as the transgene

Allelic Composition	Hsf1^tm1Anak/Hsf1^tm1Anak Hsf4^tm1Anak/Hsf4^tm1Anak
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1^tm1Anak mutation (1 available); any Hsf1 mutation (25 available)
Hsf4^tm1Anak mutation (1 available); any Hsf4 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

ruptured lens capsule ( J:93301 )

• the lens capsule is always ruptured; however, lens epithelial cell proliferation and morphology are fairly normal unlike in Hsf4^tm1Anak homozygotes

cataract ( J:93301 )

• more severe cataracts are seen compared to Hsf4^tm1Anak homozygotes

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