Phenotypes associated with this allele

• Allele Symbol: Trhr^tm1Bau
• Allele Name: targeted mutation 1, Karl Bauer
• Allele ID: MGI:3044170
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trhr^tm1Bau/Trhr^tm1Bau	involves: 129S1/Sv * 129X1/SvJ	MGI:3044691
hm2	Trhr^tm1Bau/Trhr^tm1Bau	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5637537

Genotype
MGI:3044691

hm1

• Allelic Composition: Trhr^tm1Bau/Trhr^tm1Bau
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased thyroxine level ( J:90365 )

• thyroxine levels are decreased by a factor of 3 in homozygous mice

decreased triiodothyronine level ( J:90365 )

• triiodothyronine levels are decreased by a factor of 3 in homozygous mice

decreased circulating prolactin level ( J:90365 )

• prolactin levels are 13% and 37% of wild-type in female and male homozygotes respectively

reproductive system

reproductive system phenotype ( J:90365 )

N • despite decreased prolactin levels females become pregnant and successfully raise pups

Genotype
MGI:5637537

hm2

• Allelic Composition: Trhr^tm1Bau/Trhr^tm1Bau
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

endocrine/exocrine glands

decreased activity of thyroid gland ( J:220755 )

♂ • mice exhibit central hypothyroidism

growth/size/body

decreased body weight ( J:220755 )

♂ • in hypothyroid mutants

weight loss ( J:220755 )

♂ • fasting-induced weight loss is higher in hypothyroid and euthyroid mutants than in wild-type mice

homeostasis/metabolism

abnormal circulating ghrelin level ( J:220755 )

♂ • hypothyroid mutants under fasting conditions show only a marginal elevation in serum ghrelin levels compared to fasting wild-type mice or euthyroid mutants

♂ • acylated ghrelin levels in the serum are similar in hypothyroid and euthyroid mutants as in wild-type mice under feeding conditions

decreased circulating ghrelin level ( J:220755 )

♂ • the fasting-induced rise in acylated ghrelin that is seen in wild-type mice is diminished in hypothyroid and in euthyroid mutants

increased circulating ghrelin level ( J:220755 )

♂ • hypothyroid mutants show elevated total ghrelin serum levels under feeding conditions compared to euthyroid mutants and wild-type mice

decreased circulating levels of thyroid hormone ( J:220755 )

♂ • mice rendered euthyroid by thyroid hormone treatment before fasting show lower serum thyroid hormone levels

♂ • however, serum thyroid hormone levels do not change in hypothyroid mutants upon fasting

decreased circulating thyroxine level ( J:220755 )

♂ • approximate 50% reduction in serum T3 and T4 concentrations

decreased circulating triiodothyronine level ( J:220755 )

♂ • approximate 50% reduction in serum T3 and T4 concentrations

increased oxygen consumption ( J:220755 )

♂ • increase in oxygen consumption under conditions of ad libitum food accessibility

♂ • hypothyroid mutants display similar oxygen consumption and locomotor activity values under fasting and feeding conditions in the first hours of the dark period unlike wild-type mice which show a mild reduction in oxygen consumption and lower locomotor activity under food deprivation conditions

♂ • however, oxygen consumption and locomotor activity decline in the second half of the fasting period as in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital hypothyroidism		DOID:0050328	OMIM:PS275200	J:220755