Phenotypes associated with this allele

• Allele Symbol: Mnt^tm1Awb
• Allele Name: targeted mutation 1, Anthony Wynshaw-Boris
• Allele ID: MGI:3044351
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mnt^tm1Awb/Mnt^tm1.1Awb Tg(MMTV-cre)4Mam/?	involves: 129S6/SvEvTac * FVB/N	MGI:3718675

Genotype
MGI:3718675

cn1

• Allelic Composition: Mnt^tm1Awb/Mnt^tm1.1Awb; Tg(MMTV-cre)4Mam/?
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:110115 )

• in 7 of 11 continuously mated females with tumor latency ranging from 6 to 24 months compared to control mice that do not develop tumors some tumors show lymphocyte invasion

• tumors are invasive carcinomas that include solid tubular carcinomas, tubular carcinomas and carcinomas with sarcomatous changes

• tumors display ductal enlargement that may or may not be pre-existing

endocrine/exocrine glands

abnormal mammary gland morphology ( J:110115 )

♀ • involution is delayed at I2, I5, and I16

♀ • apoptosis levels peak at day 5 of involution compared to day 2 in wild-type mice

♀ • apoptosis in the alveoli and ducts is delayed and fewer cells undergo apoptosis

abnormal involution of the mammary gland ( J:110115 )

♀ • during involution after weaning, mice display enlarged ducts

♀ • after involution ducts remain enlarged

♀ • nonvirgin females exhibit 90% enlarged ducts compared to 40% in nonvirgin control mice and virgin mice exhibit 50% enlarged ducts compared to 30% in virgin control mice

increased mammary adenocarcinoma incidence ( J:110115 )

• in 7 of 11 continuously mated females with tumor latency ranging from 6 to 24 months compared to control mice that do not develop tumors some tumors show lymphocyte invasion

• tumors are invasive carcinomas that include solid tubular carcinomas, tubular carcinomas and carcinomas with sarcomatous changes

• tumors display ductal enlargement that may or may not be pre-existing

integument

abnormal mammary gland morphology ( J:110115 )

♀ • involution is delayed at I2, I5, and I16

♀ • apoptosis levels peak at day 5 of involution compared to day 2 in wild-type mice

♀ • apoptosis in the alveoli and ducts is delayed and fewer cells undergo apoptosis

abnormal involution of the mammary gland ( J:110115 )

♀ • during involution after weaning, mice display enlarged ducts

♀ • after involution ducts remain enlarged

♀ • nonvirgin females exhibit 90% enlarged ducts compared to 40% in nonvirgin control mice and virgin mice exhibit 50% enlarged ducts compared to 30% in virgin control mice

increased mammary adenocarcinoma incidence ( J:110115 )

• in 7 of 11 continuously mated females with tumor latency ranging from 6 to 24 months compared to control mice that do not develop tumors some tumors show lymphocyte invasion

• tumors are invasive carcinomas that include solid tubular carcinomas, tubular carcinomas and carcinomas with sarcomatous changes

• tumors display ductal enlargement that may or may not be pre-existing