All Phenotypes Nr1i3<tm1Dgen> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nr1i3^tm1Dgen
targeted mutation 1, Deltagen
MGI:3044371

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr1i3^tm1Dgen/Nr1i3^tm1Dgen	B6.129-Nr1i3^tm1Dgen	MGI:3848014
hm2	Nr1i3^tm1Dgen/Nr1i3^tm1Dgen	involves: 129	MGI:3044373
cx3	Lep^ob/Lep^ob Nr1i3^tm1Dgen/Nr1i3^tm1Dgen	B6.Cg-Nr1i3^tm1Dgen Lep^ob	MGI:3848016

Allelic Composition	Nr1i3^tm1Dgen/Nr1i3^tm1Dgen
Genetic Background	B6.129-Nr1i3^tm1Dgen

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1i3^tm1Dgen mutation (0 available); any Nr1i3 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:149091 )

N	• when fed a high fat diet or treated with TCPOBOP, mice exhibit unaltered serum triglyceride levels unlike similarly treated wild-type mice

abnormal lipid oxidation ( J:149091 )

• mice exhibit an increase in hepatic fatty acid oxidation compared to wild-type mice

cellular

abnormal lipid oxidation ( J:149091 )

• mice exhibit an increase in hepatic fatty acid oxidation compared to wild-type mice

Allelic Composition	Nr1i3^tm1Dgen/Nr1i3^tm1Dgen
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1i3^tm1Dgen mutation (0 available); any Nr1i3 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased susceptibility to weight loss ( J:89824 )

• on a restricted calorie diet homozygous mice lost significantly more weight and lost weight for a longer period of time before reaching a plateau compared to wild-type mice

• the increased weight loss seen in homozygous mice was the result of normal loss of fat and not of lean mass

homeostasis/metabolism

abnormal thyroxine level ( J:89824 )

• following a 24 hour fast serum thyroxine levels do not significantly decrease unlike in wild-type mice

abnormal triiodothyronine level ( J:89824 )

• following a 24 hour fast serum triiodothyronine levels do not significantly decrease unlike in wild-type mice

decreased physiological sensitivity to xenobiotic ( J:89824 )

• treatment with 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene does not reduce serum triiodothyronine or thyroxine concentrations unlike in wild-type mice

Allelic Composition	Lep^ob/Lep^ob Nr1i3^tm1Dgen/Nr1i3^tm1Dgen
Genetic Background	B6.Cg-Nr1i3^tm1Dgen Lep^ob

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lep^ob mutation (5 available); any Lep mutation (21 available)
Nr1i3^tm1Dgen mutation (0 available); any Nr1i3 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating triglyceride level ( J:149091 )

• mice exhibit decreased serum triglyceride levels compared with Lep^ob homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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