All Phenotypes Fgfr2<tm1.1Dor> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgfr2^tm1.1Dor/Fgfr2^tm1.1Dor	involves: 129X1/SvJ	MGI:3044690
ht2	Fgfr2^tm1.1Dor/Fgfr2^hob	involves: 129X1/SvJ * C57BL/6J * FVB/N	MGI:5614321
ht3	Fgfr2^tm1.1Dor/Fgfr2^svs	involves: 129X1/SvJ * CXB5/ByJ * FVB/N	MGI:3705023
cn4	Fgfr1^tm1Jpa/Fgfr1^tm1.1Jpa Fgfr2^tm1Dor/Fgfr2^tm1.1Dor Twist2^tm1(cre)Dor/Twist2⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3813486
cn5	Fgfr1^tm1Jpa/Fgfr1⁺ Fgfr2^tm1Dor/Fgfr2^tm1.1Dor Twist2^tm1(cre)Dor/Twist2⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3813484
cn6	Fgfr2^tm1Dor/Fgfr2^tm1.1Dor Twist2^tm1(cre)Dor/Twist2⁺	involves: 129X1/SvJ	MGI:3044704
cx7	Fgfr2^tm1.1Dor/Fgfr2⁺ Spry2^tm1.1Mrt/Spry2^tm1.1Mrt	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:3702560
cx8	Fgfr2^tm1.1Dor/Oat^rhg	involves: AKR/J * C57BL/6J * C57BL/6JEi * FVB/N	MGI:6162253

Allelic Composition	Fgfr2^tm1.1Dor/Fgfr2^tm1.1Dor
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2^tm1.1Dor mutation (0 available); any Fgfr2 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:90391 )

• death between E10 and E11, putatively due to the failure to form a functional placenta

embryo

absent limb buds ( J:90391 )

• fetuses did not develop limb bud

abnormal placenta development ( J:90391 )

• failure to form a functional placenta

limbs/digits/tail

absent limb buds ( J:90391 )

• fetuses did not develop limb bud

Allelic Composition	Fgfr2^tm1.1Dor/Fgfr2^hob
Genetic Background	involves: 129X1/SvJ * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2^hob mutation (0 available); any Fgfr2 mutation (90 available)
Fgfr2^tm1.1Dor mutation (0 available); any Fgfr2 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased fetal size ( J:216825 )

• slightly smaller than wild-type at E14.5

limbs/digits/tail

absent limbs ( J:216825 )

• embryos lack limbs

reproductive system

primary sex reversal ( J:216825 )

• XY gonads exhibit an ovarian morphology and absence of Sertoli cell markers, indicating complete gonadal sex reversal

respiratory system

pulmonary hypoplasia ( J:216825 )

• lung hypoplasia

Allelic Composition	Fgfr2^tm1.1Dor/Fgfr2^svs
Genetic Background	involves: 129X1/SvJ * CXB5/ByJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2^svs mutation (1 available); any Fgfr2 mutation (90 available)
Fgfr2^tm1.1Dor mutation (0 available); any Fgfr2 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal branching involved in seminal vesicle morphogenesis ( J:119935 )

• at P5, seminal vesicles have not started branching morphogenesis

• adult seminal vesicles lack all branching

reproductive system

abnormal branching involved in seminal vesicle morphogenesis ( J:119935 )

• at P5, seminal vesicles have not started branching morphogenesis

• adult seminal vesicles lack all branching

Allelic Composition	Fgfr1^tm1Jpa/Fgfr1^tm1.1Jpa Fgfr2^tm1Dor/Fgfr2^tm1.1Dor Twist2^tm1(cre)Dor/Twist2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm1.1Jpa mutation (0 available); any Fgfr1 mutation (222 available)
Fgfr1^tm1Jpa mutation (0 available); any Fgfr1 mutation (222 available)
Fgfr2^tm1.1Dor mutation (0 available); any Fgfr2 mutation (90 available)
Fgfr2^tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Twist2^tm1(cre)Dor mutation (0 available); any Twist2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal small intestine morphology ( J:139005 )

• there is about a third reduction in the length of the small intestine at E18.5 compared to controls

abnormal small intestine crypts of Lieberkuhn morphology ( J:139005 )

• premature crypt-like structures occur in the small intestine of E18.5 embryos before the appearance of paneth cells

abnormal digestive system physiology ( J:139005 )

• proliferation of fibroblasts found in the proximal and distal small intestine mesenchyme is significantly reduced at E18.5

endocrine/exocrine glands

abnormal small intestine crypts of Lieberkuhn morphology ( J:139005 )

• premature crypt-like structures occur in the small intestine of E18.5 embryos before the appearance of paneth cells

Allelic Composition	Fgfr1^tm1Jpa/Fgfr1⁺ Fgfr2^tm1Dor/Fgfr2^tm1.1Dor Twist2^tm1(cre)Dor/Twist2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm1Jpa mutation (0 available); any Fgfr1 mutation (222 available)
Fgfr2^tm1.1Dor mutation (0 available); any Fgfr2 mutation (90 available)
Fgfr2^tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Twist2^tm1(cre)Dor mutation (0 available); any Twist2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal small intestine morphology ( J:139005 )

• there is about a 15% reduction in the length of the small intestine at E18.5 compared to controls

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal osteoclast differentiation ( J:90391 )

• osteoclasts were more mature (larger) than in control mice, but osteoclast activity did not differ from that of wild-type

decreased cell proliferation ( J:90391 )

• impaired osteoblast proliferation

• no increase in osteoblast apoptosis

abnormal osteoblast physiology ( J:90391 )

• the mineral apposition rate (MAR) was undetectable at 3 and 4 weeks of age

craniofacial

domed cranium ( J:90391 )

growth/size/body

disproportionate dwarf ( J:90391 )

• characterized by reduced bone growth

postnatal growth retardation ( J:90391 )

• mice were 40% to 50% smaller than wild-type controls at 4 weeks of age

• normal growth resumed but adult mice remained 30% to 40% smaller than wild-type controls

limbs/digits/tail

short femur ( J:90391 )

• reduced length

skeleton

abnormal osteoblast physiology ( J:90391 )

• the mineral apposition rate (MAR) was undetectable at 3 and 4 weeks of age

abnormal appendicular skeleton morphology ( J:90391 )

• shortened appendicular skeleton

short femur ( J:90391 )

• reduced length

abnormal long bone metaphysis morphology ( J:90391 )

• 40% decrease in metaphyseal area due to a reduction in the trabecular zone length and width

abnormal axial skeleton morphology ( J:90391 )

• shortened axial skeleton

domed cranium ( J:90391 )

abnormal vertebrae morphology ( J:90391 )

abnormal thoracic vertebrae morphology ( J:90391 )

abnormal cervical vertebrae morphology ( J:90391 )

abnormal vertebrae development ( J:90391 )

• observed in some mice

• non-ossified gap in the dorsal midline of both the cervical and thoracic vertebrae

absent vertebral spinous process ( J:90391 )

decreased bone mineral density ( J:90391 )

• bone mineral density was reduced in all mice

• though density increased with age, it remained decreased relative to that of wild-type

decreased osteoblast cell number ( J:90391 )

• while osteoblast differentiation was not affected, osteogenic regions contained fewer osteoblasts due to impaired proliferation

abnormal joint morphology ( J:90391 )

• several tarsal joins failed to develop, putatively due to a a failure of cavitation of the cartilaginous anlage prior to ossificiation of these bones

abnormal skeleton development ( J:90391 )

• skeletal dwarfism and decreased bone density

• decreased amount of trabecular bone; in some cases it was absent

abnormal osteoclast differentiation ( J:90391 )

• osteoclasts were more mature (larger) than in control mice, but osteoclast activity did not differ from that of wild-type

abnormal long bone hypertrophic chondrocyte zone ( J:90391 )

• reduced hypertrophic chondrocyte zone

hematopoietic system

abnormal osteoclast differentiation ( J:90391 )

• osteoclasts were more mature (larger) than in control mice, but osteoclast activity did not differ from that of wild-type

immune system

abnormal osteoclast differentiation ( J:90391 )

• osteoclasts were more mature (larger) than in control mice, but osteoclast activity did not differ from that of wild-type

Allelic Composition	Fgfr2^tm1.1Dor/Fgfr2⁺ Spry2^tm1.1Mrt/Spry2^tm1.1Mrt
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2^tm1.1Dor mutation (0 available); any Fgfr2 mutation (90 available)
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:119280 )

N	• unlike in mice homozygous for the Spry2 allele alone, no diastema tooth formation is seen

Allelic Composition	Fgfr2^tm1.1Dor/Oat^rhg
Genetic Background	involves: AKR/J * C57BL/6J * C57BL/6JEi * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2^tm1.1Dor mutation (0 available); any Fgfr2 mutation (90 available)
Oat^rhg mutation (1 available); any Oat mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:213842 )

• double heterozygotes have normal vibrissae, fur and overall growth rate

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