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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Artm1Reb
targeted mutation 1, Robert E Braun
MGI:3044436
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Artm1Reb/Y
Tg(Amh-cre)8815Reb/?
involves: 129S4/SvJaeSor * FVB/N MGI:3044688
ot2
Artm1Reb/Y involves: 129S4/SvJaeSor MGI:3044687


Genotype
MGI:3044688
cn1
Allelic
Composition
Artm1Reb/Y
Tg(Amh-cre)8815Reb/?
Genetic
Background
involves: 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm1Reb mutation (0 available); any Ar mutation (23 available)
Tg(Amh-cre)8815Reb mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• mature sperm undetectable in epididymis
• many highly vacuolated spermatids

endocrine/exocrine glands
• seminal vesicle reduced in weight about 20%
• normal tubules of stages I-VIII are missing
• elongated spermatids absent
• testis weight about 40% less than normal
• serum albumin is detected in adluminal compartment of seminiferous tubules; an indication of Sertoli cell tight junction barrier dysfunction

homeostasis/metabolism

reproductive system
• mature sperm undetectable in epididymis
• many highly vacuolated spermatids
• seminal vesicle reduced in weight about 20%
• normal tubules of stages I-VIII are missing
• elongated spermatids absent
• testis weight about 40% less than normal
• serum albumin is detected in adluminal compartment of seminiferous tubules; an indication of Sertoli cell tight junction barrier dysfunction




Genotype
MGI:3044687
ot2
Allelic
Composition
Artm1Reb/Y
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm1Reb mutation (0 available); any Ar mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• reproductive behavior normal

cellular
• mature sperm numbers about 3.9% of normal in epididymis

endocrine/exocrine glands
• seminal vesicle reduced in weight about 20%
• some abnormal seminiferous tubules present
• degenerating elongated spermatids frequently seen
• testis weight about 19% less than normal

homeostasis/metabolism

reproductive system
• mature sperm numbers about 3.9% of normal in epididymis
• seminal vesicle reduced in weight about 20%
• some abnormal seminiferous tubules present
• degenerating elongated spermatids frequently seen
• testis weight about 19% less than normal





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory