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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Edn1tm1Ywa
targeted mutation 1, Masashi Yanagisawa
MGI:3044563
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Edn1tm1Ywa/Edn1tm1Ywa involves: 129S6/SvEvTac MGI:5490275
cn2
 		Edn1tm1Ywa/Edn1tm1Ywa
Tg(AQP2-cre)2Dek/0 		involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3695303
cn3
 		Edn1tm1Ywa/Edn1tm1Ywa
Tg(Aqp2-cre)1Dek/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3714388
cn4
 		Edn1tm1Ywa/Edn1tm1Ywa
Tg(Tek-cre)1Ywa/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:5490276
cn5
 		Edn1tm1Ywa/Edn1tm1Ywa
Tg(Myh6-cre)2182Mds/0 		involves: 129S6/SvEvTac * FVB/N MGI:3044594
cn6
 		Edn1tm1Ywa/Edn1tm1Ywa
Tg(AQP2-cre)2Dek/0 		involves: C57BL/6 * CBA MGI:3054063


Genotype
MGI:5490275
hm1
Allelic
Composition		 Edn1tm1Ywa/Edn1tm1Ywa
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn1tm1Ywa mutation (1 available); any Edn1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:196635 )
• mice grow normally with no detectable abnormalities




Genotype
MGI:3695303
cn2
Allelic
Composition		 Edn1tm1Ywa/Edn1tm1Ywa
Tg(AQP2-cre)2Dek/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn1tm1Ywa mutation (1 available); any Edn1 mutation (26 available)
Tg(AQP2-cre)2Dek mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased systemic arterial systolic blood pressure ( J:116002 )
• mice have significantly elevated systolic blood pressure compared to controls as well as Ednra and Ednrb conditional knockout mice on a normal sodium diet
• on a high sodium diet, systolic blood pressure increases significantly compared to controls; change in BP between normal and high sodium diets is much greater than in Ednra or Ednrb conditional mutants




Genotype
MGI:3714388
cn3
Allelic
Composition		 Edn1tm1Ywa/Edn1tm1Ywa
Tg(Aqp2-cre)1Dek/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn1tm1Ywa mutation (1 available); any Edn1 mutation (26 available)
Tg(Aqp2-cre)1Dek mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating antidiuretic hormone level ( J:104785 )
• levels are significantly decreased in conditional mutants compared to controls during normal water diet, and levels are essentially zero during high water intake
decreased circulating sodium level ( J:104785 )
• mice tend to have lower plasma sodium concentration and plasma osmolality than controls but differences do not reach significance
abnormal urine homeostasis ( J:104785 )
• more urinary excretion of endothelin-1 is seen in mutants over 6 hour period following water loading compared to controls
increased urine osmolality ( J:104785 )
• with chronic administration (for 7 days) of 1-desamno-8-D-arginine vasopressin (DDAVP) increases urine osmolality in mutants but not in controls; elevation does not persist past 3 days of DDAVP administration

renal/urinary system
renal/urinary system phenotype ( J:104785 )
N
• mutant and control animals display similar renal function (volume of urine excreted, osmolyte secretion, plasma osmolality, or plasma sodium concentration) under normal and high water intake
abnormal urine homeostasis ( J:104785 )
• more urinary excretion of endothelin-1 is seen in mutants over 6 hour period following water loading compared to controls
increased urine osmolality ( J:104785 )
• with chronic administration (for 7 days) of 1-desamno-8-D-arginine vasopressin (DDAVP) increases urine osmolality in mutants but not in controls; elevation does not persist past 3 days of DDAVP administration
abnormal kidney physiology ( J:104785 )
• antidiuretic hormone-induced cyclic AMP accumulation is higher in mutant inner medullary collecting ducts than in control tissue
oliguria ( J:104785 )
• mutants show reduced water excretion for up to 3 hours after acute water loading




Genotype
MGI:5490276
cn4
Allelic
Composition		 Edn1tm1Ywa/Edn1tm1Ywa
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn1tm1Ywa mutation (1 available); any Edn1 mutation (26 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:196635 )
N
• mice exhibit normal heart weight and rate
• mice exhibit normal response to acute administration of vasoactive substances (captopril, angiotensin II, phenylephrine or bradykinin)
decreased mean systemic arterial blood pressure ( J:196635 )
• in light and dark phases though less pronounced in the dark phase

embryo
embryo phenotype ( J:196635 )
N
• mice do not exhibit developmental defects




Genotype
MGI:3044594
cn5
Allelic
Composition		 Edn1tm1Ywa/Edn1tm1Ywa
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn1tm1Ywa mutation (1 available); any Edn1 mutation (26 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased response of heart to induced stress ( J:90390 , J:96386 )
• mice are resistant to hyperthyroid cardiac hypertrophy, showing a 57% reduction in cardiac hypertrophy in response to tri-iodothyronine (T3) relative to control mice (J:90390)
• left ventricular mass is increased by 3% in response to T3, compared to a 27% increase observed in similarly treated control mice (J:90390)
• the magnitude of Trypanosoma cruzi infection-associated cardiomyopathy is significantly less than in controls (J:96386)

homeostasis/metabolism
decreased response of heart to induced stress ( J:90390 , J:96386 )
• mice are resistant to hyperthyroid cardiac hypertrophy, showing a 57% reduction in cardiac hypertrophy in response to tri-iodothyronine (T3) relative to control mice (J:90390)
• left ventricular mass is increased by 3% in response to T3, compared to a 27% increase observed in similarly treated control mice (J:90390)
• the magnitude of Trypanosoma cruzi infection-associated cardiomyopathy is significantly less than in controls (J:96386)




Genotype
MGI:3054063
cn6
Allelic
Composition		 Edn1tm1Ywa/Edn1tm1Ywa
Tg(AQP2-cre)2Dek/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn1tm1Ywa mutation (1 available); any Edn1 mutation (26 available)
Tg(AQP2-cre)2Dek mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
hypertension ( J:91968 )
• mutants are hypertensive compared to littermates that do not express cre
salt-sensitive hypertension ( J:91968 )
• on a high salt diet systolic blood pressure rises in mutants but not littermate control

renal/urinary system
decreased urine sodium level ( J:91968 )
• on a high salt diet decreased Na excretion is seen for the first 3 days in mutants compared to littermate controls

homeostasis/metabolism
decreased urine sodium level ( J:91968 )
• on a high salt diet decreased Na excretion is seen for the first 3 days in mutants compared to littermate controls




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory