Phenotypes associated with this allele

• Allele Symbol: Rgs1^tm1Jhk
• Allele Name: targeted mutation 1, John H Kehrl
• Allele ID: MGI:3044786
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rgs1^tm1Jhk/Rgs1^tm1Jhk	B6.129P2-Rgs1^tm1Jhk	MGI:3044787

Genotype
MGI:3044787

hm1

• Allelic Composition: Rgs1^tm1Jhk/Rgs1^tm1Jhk
• Genetic Background: B6.129P2-Rgs1^tm1Jhk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enhanced B cell migration ( J:90780 )

• B cell migration in response to chemokines is increased in homozygous mutants

decreased plasma cell number ( J:90780 )

• the number of IgG positive cells in the spenic red pulp is decreased

• after immunization the number of IgG, IgA, and IgM secreting cells in the blood are decreased rather than increased in homozygous mutants

increased marginal zone B cell number ( J:90780 )

• the number of B cells with a marginal zone phenotype are increased in the spleens of homozygous mutants

abnormal spleen germinal center morphology ( J:90780 )

• spleens from homozygous mutants have a significant number of germinal centeers without immunization

• following immunization germinal centers appear more rapidly, reach a higher density, and resolve more slowly in homozygous mutants compared to wild-type mice

abnormal B cell calcium ion homeostasis ( J:90780 )

• follicular B cells respond to chemokines with an increased and prolonged elevation of intracellular calcium compared to wild-type mice

• reexposure of B cells from homozygous mutants to the same chemokine increases the intracellular calcium response instead of decreasing the response as in wild-type mice

increased immunoglobulin level ( J:90780 )

• levels of IgG2a and IgG2b in the serum were 10-fold and 3 fold greater than those in wild-type mice while concentrations of other immunoglobins were similar to wild-type

• after immunization IgA response in homozygous mutants was greater than that in wild-type mice at all times

cellular

enhanced B cell migration ( J:90780 )

• B cell migration in response to chemokines is increased in homozygous mutants

homeostasis/metabolism

abnormal B cell calcium ion homeostasis ( J:90780 )

• follicular B cells respond to chemokines with an increased and prolonged elevation of intracellular calcium compared to wild-type mice

• reexposure of B cells from homozygous mutants to the same chemokine increases the intracellular calcium response instead of decreasing the response as in wild-type mice

immune system

enhanced B cell migration ( J:90780 )

• B cell migration in response to chemokines is increased in homozygous mutants

decreased plasma cell number ( J:90780 )

• the number of IgG positive cells in the spenic red pulp is decreased

• after immunization the number of IgG, IgA, and IgM secreting cells in the blood are decreased rather than increased in homozygous mutants

increased marginal zone B cell number ( J:90780 )

• the number of B cells with a marginal zone phenotype are increased in the spleens of homozygous mutants

abnormal spleen germinal center morphology ( J:90780 )

• spleens from homozygous mutants have a significant number of germinal centeers without immunization

• following immunization germinal centers appear more rapidly, reach a higher density, and resolve more slowly in homozygous mutants compared to wild-type mice

abnormal B cell calcium ion homeostasis ( J:90780 )

• follicular B cells respond to chemokines with an increased and prolonged elevation of intracellular calcium compared to wild-type mice

• reexposure of B cells from homozygous mutants to the same chemokine increases the intracellular calcium response instead of decreasing the response as in wild-type mice

increased immunoglobulin level ( J:90780 )

• levels of IgG2a and IgG2b in the serum were 10-fold and 3 fold greater than those in wild-type mice while concentrations of other immunoglobins were similar to wild-type

• after immunization IgA response in homozygous mutants was greater than that in wild-type mice at all times

small Peyer's patches ( J:90780 )

• following immunization Peyer's patches shrink in homozygous mutants rather than enlarging as in wild-type mice

abnormal dendritic cell physiology ( J:89680 )

• nearly twice as many immature dendritic cells from homozygous mice migrate in response to chemokine stimulation compared to wild-type mice