Phenotypes associated with this allele

• Allele Symbol: Hc¹
• Allele Name: sufficient
• Allele ID: MGI:3044820
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hc^1/Hc^1	Not Specified	MGI:3718225
cx2	Hc^1/Hc^1 Tg(APPswe,PSEN1dE9)85Dbo/0	D2.Cg-Tg(APPswe,PSEN1dE9)85Dbo	MGI:5702670
cx3	Hc^1/? Tg(TcrbBL17)1Lmor/0	involves: DBA/1J * SWR/J	MGI:3790655

Genotype
MGI:3718225

hm1

• Allelic Composition: Hc¹/Hc¹
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:5016 )

• This is equivalent to the wild-type allele.

Genotype
MGI:5702670

cx2

• Allelic Composition: Hc¹/Hc¹; Tg(APPswe,PSEN1dE9)85Dbo/0
• Genetic Background: D2.Cg-Tg(APPswe,PSEN1dE9)85Dbo

homeostasis/metabolism

amyloid beta deposits ( J:227541 )

• Background Sensitivity: the complement pathway does not impact plaque deposition in the cortex, the number of plaques is the same as that in transgene carriers with the DBA/2J allele of Hc

behavior/neurological

convulsive seizures ( J:227541 )

• Background Sensitivity: despite the presence of functional hemolytic complement these mice have the same rate of lethal seizures as transgenics with the non-functional DBA/2J allele

mortality/aging

premature death ( J:227541 )

nervous system

nervous system phenotype ( J:227541 )

N • no significant differences are found in cortical neuron number in complement deficient versus functional transgene carriers

convulsive seizures ( J:227541 )

• Background Sensitivity: despite the presence of functional hemolytic complement these mice have the same rate of lethal seizures as transgenics with the non-functional DBA/2J allele

amyloid beta deposits ( J:227541 )

• Background Sensitivity: the complement pathway does not impact plaque deposition in the cortex, the number of plaques is the same as that in transgene carriers with the DBA/2J allele of Hc

Genotype
MGI:3790655

cx3

• Allelic Composition: Hc¹/?; Tg(TcrbBL17)1Lmor/0
• Genetic Background: involves: DBA/1J * SWR/J

immune system

increased susceptibility to induced arthritis ( J:134111 )

• susceptibility to collagen-induced arthritis

• trangenic animals affected with collagen-induced arthritis all carried at least one functional Hc allele

skeleton

increased susceptibility to induced arthritis ( J:134111 )

• susceptibility to collagen-induced arthritis

• trangenic animals affected with collagen-induced arthritis all carried at least one functional Hc allele