About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spred2tm1Taga
targeted mutation 1, Tetsuya Taga
MGI:3044889
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Spred2tm1Taga/Spred2tm1Taga Not Specified MGI:3044890


Genotype
MGI:3044890
hm1
Allelic
Composition		 Spred2tm1Taga/Spred2tm1Taga
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spred2tm1Taga mutation (1 available); any Spred2 mutation (222 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal definitive hematopoiesis ( J:90463 )
• E11.5 aortic cells form significantly more macrophage and granulocyte colonies in culture
• culture of the aorta-gonad-mesonephros from homozygous embryos produces 3 fold more hematopoietic cells compared to wild-type
• about 2-fold more hematopoietic cell colonies are produced in bone marrow cell cultures from homozygous mice
increased megakaryocyte cell number ( J:90463 )
• increased numbers of megakaryocytes are seen in the spleens of homozygous mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory