endocrine/exocrine glands
• reduced ability of epithelial cells of involuting mammary glands to engulf apoptotic cells
• 2-3 times more apoptotic cells found in the involuting mammary gland than in controls after 2 days
• at day 4 of involution, alveoli of involuting glands with enlarged lumina containing cell debris
• enlarged debris filled ducts still present at day 10
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• redevelopment of mammary glands is abnormal due to defects in involution process
• presence of fat pads as well as abnormal ducts and alveoli interfere with redevelopment
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• reduced production of milk proteins
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• decreased milk production
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integument
• reduced ability of epithelial cells of involuting mammary glands to engulf apoptotic cells
• 2-3 times more apoptotic cells found in the involuting mammary gland than in controls after 2 days
• at day 4 of involution, alveoli of involuting glands with enlarged lumina containing cell debris
• enlarged debris filled ducts still present at day 10
|
• redevelopment of mammary glands is abnormal due to defects in involution process
• presence of fat pads as well as abnormal ducts and alveoli interfere with redevelopment
|
• reduced production of milk proteins
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• decreased milk production
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immune system
N |
• Background Sensitivity: mice exhibit normal autoantibody levels when backcrossed to C57BL/6 for more than 8 generations
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