All Phenotypes Mfge8<tm1Osa> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mfge8^tm1Osa/Mfge8^tm1Osa	B6.129-Mfge8^tm1Osa	MGI:3694083
hm2	Mfge8^tm1Osa/Mfge8^tm1Osa	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3045535
cx3	Mfge8^tm1Osa/Mfge8^tm1Osa Timd4^tm1Osa/Timd4^tm1Osa	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5438221

Allelic Composition	Mfge8^tm1Osa/Mfge8^tm1Osa
Genetic Background	B6.129-Mfge8^tm1Osa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfge8^tm1Osa mutation (1 available); any Mfge8 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:103839 )

• reduced ability of epithelial cells of involuting mammary glands to engulf apoptotic cells

• 2-3 times more apoptotic cells found in the involuting mammary gland than in controls after 2 days

• at day 4 of involution, alveoli of involuting glands with enlarged lumina containing cell debris

• enlarged debris filled ducts still present at day 10

abnormal mammary gland growth during lactation ( J:103839 )

• redevelopment of mammary glands is abnormal due to defects in involution process

• presence of fat pads as well as abnormal ducts and alveoli interfere with redevelopment

abnormal milk composition ( J:103839 )

• reduced production of milk proteins

hypolactation ( J:103839 )

• decreased milk production

integument

abnormal involution of the mammary gland ( J:103839 )

• reduced ability of epithelial cells of involuting mammary glands to engulf apoptotic cells

• 2-3 times more apoptotic cells found in the involuting mammary gland than in controls after 2 days

• at day 4 of involution, alveoli of involuting glands with enlarged lumina containing cell debris

• enlarged debris filled ducts still present at day 10

abnormal mammary gland growth during lactation ( J:103839 )

• redevelopment of mammary glands is abnormal due to defects in involution process

• presence of fat pads as well as abnormal ducts and alveoli interfere with redevelopment

abnormal milk composition ( J:103839 )

• reduced production of milk proteins

hypolactation ( J:103839 )

• decreased milk production

immune system

immune system phenotype ( J:187181 )

N	• Background Sensitivity: mice exhibit normal autoantibody levels when backcrossed to C57BL/6 for more than 8 generations

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

impaired macrophage phagocytosis ( J:90633 )

• ability of macrophage to engulf apoptotic cells is impaired

abnormal spleen morphology ( J:90633 )

enlarged spleen ( J:90633 )

• splenomegaly develops with age

increased spleen weight ( J:90633 )

• by 40 weeks spleen weight is 3X control

spleen hyperplasia ( J:90633 )

• 2-3 times more lymphocytes in spleen but normal B cell to T cell ratio

increased spleen B cell follicle size ( J:90633 )

• enlarged follicular zones

increased spleen white pulp amount ( J:90633 )

• enlarged white pulp

immune system

impaired macrophage phagocytosis ( J:90633 )

• ability of macrophage to engulf apoptotic cells is impaired

abnormal spleen morphology ( J:90633 )

enlarged spleen ( J:90633 )

• splenomegaly develops with age

increased spleen weight ( J:90633 )

• by 40 weeks spleen weight is 3X control

spleen hyperplasia ( J:90633 )

• 2-3 times more lymphocytes in spleen but normal B cell to T cell ratio

increased spleen B cell follicle size ( J:90633 )

• enlarged follicular zones

increased spleen white pulp amount ( J:90633 )

• enlarged white pulp

increased anti-double stranded DNA antibody level ( J:225063 )

endocrine/exocrine glands

abnormal lactation ( J:103839 )

• reduced weights of later litters and death of 20-30% of pups

integument

abnormal lactation ( J:103839 )

• reduced weights of later litters and death of 20-30% of pups

cellular

impaired macrophage phagocytosis ( J:90633 )

• ability of macrophage to engulf apoptotic cells is impaired

growth/size/body

enlarged spleen ( J:90633 )

• splenomegaly develops with age

increased spleen weight ( J:90633 )

• by 40 weeks spleen weight is 3X control

spleen hyperplasia ( J:90633 )

• 2-3 times more lymphocytes in spleen but normal B cell to T cell ratio

Allelic Composition	Mfge8^tm1Osa/Mfge8^tm1Osa Timd4^tm1Osa/Timd4^tm1Osa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfge8^tm1Osa mutation (1 available); any Mfge8 mutation (23 available)
Timd4^tm1Osa mutation (1 available); any Timd4 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired macrophage phagocytosis ( J:187181 )

increased anti-nuclear antigen antibody level ( J:187181 )

• by 30 weeks of age in female mice

• at 7 weeks after anti-Tnfa antibody treatment in female mice

• however, male mice exhibit normal autoantibody levels

increased anti-double stranded DNA antibody level ( J:187181 )

• by 30 weeks of age in female mice

• however, male mice exhibit normal autoantibody levels

hematopoietic system

impaired macrophage phagocytosis ( J:187181 )

cellular

impaired macrophage phagocytosis ( J:187181 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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