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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mfge8tm1Osa
targeted mutation 1, Shigekazu Nagata
MGI:3044898
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mfge8tm1Osa/Mfge8tm1Osa B6.129-Mfge8tm1Osa MGI:3694083
hm2
Mfge8tm1Osa/Mfge8tm1Osa involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3045535
cx3
Mfge8tm1Osa/Mfge8tm1Osa
Timd4tm1Osa/Timd4tm1Osa
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5438221


Genotype
MGI:3694083
hm1
Allelic
Composition
Mfge8tm1Osa/Mfge8tm1Osa
Genetic
Background
B6.129-Mfge8tm1Osa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfge8tm1Osa mutation (1 available); any Mfge8 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• reduced ability of epithelial cells of involuting mammary glands to engulf apoptotic cells
• 2-3 times more apoptotic cells found in the involuting mammary gland than in controls after 2 days
• at day 4 of involution, alveoli of involuting glands with enlarged lumina containing cell debris
• enlarged debris filled ducts still present at day 10
• redevelopment of mammary glands is abnormal due to defects in involution process
• presence of fat pads as well as abnormal ducts and alveoli interfere with redevelopment
• reduced production of milk proteins
• decreased milk production

integument
• reduced ability of epithelial cells of involuting mammary glands to engulf apoptotic cells
• 2-3 times more apoptotic cells found in the involuting mammary gland than in controls after 2 days
• at day 4 of involution, alveoli of involuting glands with enlarged lumina containing cell debris
• enlarged debris filled ducts still present at day 10
• redevelopment of mammary glands is abnormal due to defects in involution process
• presence of fat pads as well as abnormal ducts and alveoli interfere with redevelopment
• reduced production of milk proteins
• decreased milk production

immune system
N
• Background Sensitivity: mice exhibit normal autoantibody levels when backcrossed to C57BL/6 for more than 8 generations




Genotype
MGI:3045535
hm2
Allelic
Composition
Mfge8tm1Osa/Mfge8tm1Osa
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfge8tm1Osa mutation (1 available); any Mfge8 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• ability of macrophage to engulf apoptotic cells is impaired
• splenomegaly develops with age
• by 40 weeks spleen weight is 3X control
• 2-3 times more lymphocytes in spleen but normal B cell to T cell ratio
• enlarged follicular zones
• enlarged white pulp

immune system
• ability of macrophage to engulf apoptotic cells is impaired
• splenomegaly develops with age
• by 40 weeks spleen weight is 3X control
• 2-3 times more lymphocytes in spleen but normal B cell to T cell ratio
• enlarged follicular zones
• enlarged white pulp

endocrine/exocrine glands
• reduced weights of later litters and death of 20-30% of pups

integument
• reduced weights of later litters and death of 20-30% of pups

cellular
• ability of macrophage to engulf apoptotic cells is impaired

growth/size/body
• splenomegaly develops with age
• by 40 weeks spleen weight is 3X control
• 2-3 times more lymphocytes in spleen but normal B cell to T cell ratio




Genotype
MGI:5438221
cx3
Allelic
Composition
Mfge8tm1Osa/Mfge8tm1Osa
Timd4tm1Osa/Timd4tm1Osa
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfge8tm1Osa mutation (1 available); any Mfge8 mutation (23 available)
Timd4tm1Osa mutation (1 available); any Timd4 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• by 30 weeks of age in female mice
• at 7 weeks after anti-Tnfa antibody treatment in female mice
• however, male mice exhibit normal autoantibody levels
• by 30 weeks of age in female mice
• however, male mice exhibit normal autoantibody levels

hematopoietic system

cellular





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory