About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dll1tm1Mjo
targeted mutation 1, Michael J Owen
MGI:3044907
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Dll1tm1Mjo/Dll1tm1Mjo
Tg(Cdh5-cre/ERT2)1Rha/0 		involves: 129 MGI:3848985
cn2
 		Dll1tm1Mjo/Dll1tm1Mjo
Tg(KRT5-cre)1Tak/?
Tg(Mx1-cre)1Cgn/? 		involves: 129 * C3H * C57BL/6 * CBA MGI:3045468
cn3
 		Dll1tm1Mjo/Dll1tm1Mjo
Tg(Mx1-cre)1Cgn/? 		involves: 129 * C57BL/6 * CBA MGI:3045467
cn4
 		Dll1tm1Mjo/Dll1tm1Mjo
Tg(Six2-EGFP/cre)1Amc/0 		involves: 129 * C57BL/6 * CD-1 MGI:5523690
cn5
 		Dll1tm1Mjo/Dll1tm1Mjo
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd * C57BL/6J MGI:3624333
cn6
 		Dll1tm1Mjo/Dll1tm1Mjo
Jag1tm1Frad/Jag1+
Tg(Six2-EGFP/cre)1Amc/0 		involves: 129/Sv * C57BL/6 * CD-1 MGI:5523691
cn7
 		Dll1tm1Mjo/Dll1tm1Mjo
Jag1tm1Frad/Jag1tm1Frad
Tg(Six2-EGFP/cre)1Amc/0 		involves: 129/Sv * C57BL/6 * CD-1 MGI:5523692
cn8
 		Dll1tm1Mjo/Dll1+
Jag1tm1Frad/Jag1tm1Frad
Tg(Six2-EGFP/cre)1Amc/0 		involves: 129/Sv * C57BL/6 * CD-1 MGI:5523693
cn9
 		Dll1tm1Mjo/Dll1+
Jag1tm1Frad/Jag1+
Tg(Six2-EGFP/cre)1Amc/0 		involves: 129/Sv * C57BL/6 * CD-1 MGI:5523694


Genotype
MGI:3848985
cn1
Allelic
Composition		 Dll1tm1Mjo/Dll1tm1Mjo
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (4 available); any Dll1 mutation (46 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
artery stenosis ( J:148902 )
• lumens of large arteries show a reduction in diameters after tamoxifen induction at E18.5, with no significant differences in arterial wall thickness
aorta stenosis ( J:148902 )
• lumen shows a reduction in diameter compared to controls
abnormal capillary branching pattern ( J:148902 )
• significant increase in capillary branch points in the skin is observed at E17.5
abnormal skin vasculature morphology ( J:148902 )
• significant increase in capillary branch points in the skin is observed at E17.5

integument
abnormal skin vasculature morphology ( J:148902 )
• significant increase in capillary branch points in the skin is observed at E17.5




Genotype
MGI:3045468
cn2
Allelic
Composition		 Dll1tm1Mjo/Dll1tm1Mjo
Tg(KRT5-cre)1Tak/?
Tg(Mx1-cre)1Cgn/?
Genetic
Background		 involves: 129 * C3H * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (4 available); any Dll1 mutation (46 available)
Tg(KRT5-cre)1Tak mutation (0 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:90630 )
N
• T cells in the thymus were unaffected




Genotype
MGI:3045467
cn3
Allelic
Composition		 Dll1tm1Mjo/Dll1tm1Mjo
Tg(Mx1-cre)1Cgn/?
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (4 available); any Dll1 mutation (46 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
absent marginal zone B cells ( J:90630 )
• absence of marginal zone B cells
• other populations of B cells as well as T cells in the spleen are normal, and B and T cell populations in the lymph nodes are normal

immune system
absent marginal zone B cells ( J:90630 )
• absence of marginal zone B cells
• other populations of B cells as well as T cells in the spleen are normal, and B and T cell populations in the lymph nodes are normal




Genotype
MGI:5523690
cn4
Allelic
Composition		 Dll1tm1Mjo/Dll1tm1Mjo
Tg(Six2-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129 * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (4 available); any Dll1 mutation (46 available)
Tg(Six2-EGFP/cre)1Amc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal nephron morphogenesis ( J:198632 )
• nephron development is mildly disrupted




Genotype
MGI:3624333
cn5
Allelic
Composition		 Dll1tm1Mjo/Dll1tm1Mjo
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (4 available); any Dll1 mutation (46 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal cochlear hair cell morphology ( J:107414 )
• hair cells in Dll1 conditional knockouts differentiate prematurely and hair cells can be seen in the apex of the cochlea at E17.5, while none are visible in control littermates
increased cochlear inner hair cell number ( J:107414 )
• by E17.5 and the inner hair-cell row seems to have been duplicated in the apex
• in rhw middle and basal regions, there are increased numbers of inner hair cells
increased cochlear outer hair cell number ( J:107414 )
• in the apex, between 6 and 8 rows of outer hair cells have formed in the mutant by E17.5
• in rhw middle and basal regions, there is one extra row of outer hair cells
decreased cochlea coiling ( J:107414 )
• at E17.5, there are fewer turns in the cochlea in the mutant compared to wild-type and in mutants the cochlea has a shorter length with an extreme broadening of the sensory patch at the apex
abnormal utricular macula morphology ( J:107414 )
• the utricular macula is severely reduced or lost
abnormal vestibular saccular macula morphology ( J:107414 )
• the saccular macula is severely reduced or lost

nervous system
abnormal cochlear hair cell morphology ( J:107414 )
• hair cells in Dll1 conditional knockouts differentiate prematurely and hair cells can be seen in the apex of the cochlea at E17.5, while none are visible in control littermates
increased cochlear inner hair cell number ( J:107414 )
• by E17.5 and the inner hair-cell row seems to have been duplicated in the apex
• in rhw middle and basal regions, there are increased numbers of inner hair cells
increased cochlear outer hair cell number ( J:107414 )
• in the apex, between 6 and 8 rows of outer hair cells have formed in the mutant by E17.5
• in rhw middle and basal regions, there is one extra row of outer hair cells




Genotype
MGI:5523691
cn6
Allelic
Composition		 Dll1tm1Mjo/Dll1tm1Mjo
Jag1tm1Frad/Jag1+
Tg(Six2-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (4 available); any Dll1 mutation (46 available)
Jag1tm1Frad mutation (0 available); any Jag1 mutation (78 available)
Tg(Six2-EGFP/cre)1Amc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
decreased nephron number ( J:198632 )
• nephron number is severely compromised, but some podocytes form




Genotype
MGI:5523692
cn7
Allelic
Composition		 Dll1tm1Mjo/Dll1tm1Mjo
Jag1tm1Frad/Jag1tm1Frad
Tg(Six2-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (4 available); any Dll1 mutation (46 available)
Jag1tm1Frad mutation (0 available); any Jag1 mutation (78 available)
Tg(Six2-EGFP/cre)1Amc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
decreased nephron number ( J:198632 )
• almost all nephrons are absent




Genotype
MGI:5523693
cn8
Allelic
Composition		 Dll1tm1Mjo/Dll1+
Jag1tm1Frad/Jag1tm1Frad
Tg(Six2-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (4 available); any Dll1 mutation (46 available)
Jag1tm1Frad mutation (0 available); any Jag1 mutation (78 available)
Tg(Six2-EGFP/cre)1Amc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
absent podocytes ( J:198632 )
• podocytes are almost entirely absent; one allele of Dll1 cannot support podocyte production




Genotype
MGI:5523694
cn9
Allelic
Composition		 Dll1tm1Mjo/Dll1+
Jag1tm1Frad/Jag1+
Tg(Six2-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (4 available); any Dll1 mutation (46 available)
Jag1tm1Frad mutation (0 available); any Jag1 mutation (78 available)
Tg(Six2-EGFP/cre)1Amc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:198632 )
N
• nephron development appears essentially normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory