Phenotypes associated with this allele

• Allele Symbol: Slc6a9^tm1Jtc
• Allele Name: targeted mutation 1, Joseph T Coyle
• Allele ID: MGI:3045030
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc6a9^tm1Jtc/Slc6a9^tm1Jtc	involves: 129S6/SvEvTac * 129X1/SvJ	MGI:3045034
ht2	Slc6a9^tm1Jtc/Slc6a9^+	involves: 129S6/SvEvTac * 129X1/SvJ	MGI:3045035

Genotype
MGI:3045034

hm1

• Allelic Composition: Slc6a9^tm1Jtc/Slc6a9^tm1Jtc
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:90689 )

• homozygous mice die within 12 hours of birth from respiratory distress

nervous system

abnormal nervous system physiology ( J:90689 )

• on P1 homozygous pups have negligible glycine uptake

Genotype
MGI:3045035

ht2

• Allelic Composition: Slc6a9^tm1Jtc/Slc6a9⁺
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

behavior/neurological

abnormal spatial learning ( J:90689 )

• when the platform is removed from the water maze heterozygous mice spend more time in the former platform quadrant suggesting better retention of the platform position

nervous system

abnormal nervous system physiology ( J:90689 )

• at P1 and 12 weeks glycine uptake in brain homogenates is significantly reduced compared to wild-type

abnormal sensorimotor gating ( J:90689 )

• low concentrations of amphetamine fail to disrupt pre-pulse inhibition in heterozygous mice

abnormal NMDA-mediated synaptic currents ( J:90689 )

• perfusion with glycine or D-serine fails to increase the amplitude of NMDA receptor currents of CA1 pyramidal cells