Phenotypes associated with this allele

• Allele Symbol: Gfra1^tm1Bjh
• Allele Name: targeted mutation 1, B J Hoffer
• Allele ID: MGI:3045109
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gfra1^tm1Bjh/Gfra1^tm1Bjh	either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)	MGI:3045133

Genotype
MGI:3045133

hm1

• Allelic Composition: Gfra1^tm1Bjh/Gfra1^tm1Bjh
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:60458 )

• although homozygotes are born in expected proportions, they all die within 24 hours

digestive/alimentary system

abnormal digestive system morphology ( J:60458 )

• gasterointestinal tract is enlarged

abnormal intestine morphology ( J:60458 )

• thin intestinal walls

• villi were abnormal

• large masses of degenerating or necrotic tissue in the lumen of the intestine

abnormal digestion ( J:60458 )

• milk in stomach failed to enter intestine

renal/urinary system

abnormal kidney development ( J:60458 )

• renal dysgenesis or agenesis by birth

absent kidney ( J:60458 )

• 80% of newborns lack kidneys

abnormal ureter morphology ( J:60458 )

• abnormal associations of the ureter to the metanephros, when present

absent ureter ( J:60458 )

• 80% of newborns lack ureters

nervous system

abnormal enteric nervous system morphology ( J:60458 )

• reduced or absent innervation in the intestines

abnormal parasympathetic system morphology ( J:89887 )

abnormal otic ganglion morphology ( J:89887 )

• otic ganglion is undetectable at birth

abnormal pterygopalatine ganglion morphology ( J:89887 )

• sphenopalatine ganglion is undetectable at birth