Phenotypes associated with this allele

• Allele Symbol: Jak2^tm1Kpf
• Allele Name: targeted mutation 1, Klaus Pfeffer
• Allele ID: MGI:3045167
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jak2^tm1Kpf/Jak2^tm1Kpf	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)	MGI:3045170

Genotype
MGI:3045170

hm1

• Allelic Composition: Jak2^tm1Kpf/Jak2^tm1Kpf
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:47298 )

• death between E12 and E13, with near complete resorption by E15

hematopoietic system

absent common myeloid progenitor cells ( J:47298 )

• BFU-E and CFU-E colonies are absent from the fetal liver

anemia ( J:47298 )

impaired hematopoiesis ( J:47298 )

• while primitive erythroctyes are present, definitive erythropoiesis is blocked

• B lymphopoiesis is intact