Phenotypes associated with this allele

• Allele Symbol: Spi1^tm1.1Dgt
• Allele Name: targeted mutation 1.1, Daniel G Tenen
• Allele ID: MGI:3045207
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spi1^tm1.1Dgt/Spi1^tm1.1Dgt	involves: 129S1/Sv * 129X1/SvJ	MGI:3045216

Genotype
MGI:3045216

hm1

• Allelic Composition: Spi1^tm1.1Dgt/Spi1^tm1.1Dgt
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:90331 )

• become rapidly moribund or die between 3 and 8 months of age

neoplasm

increased tumor incidence ( J:90331 )

increased T cell derived lymphoma incidence ( J:90331 )

increased leukemia incidence ( J:90331 )

• acute myeloid leukemia develops by 3 to 8 months of age

hematopoietic system

increased T cell derived lymphoma incidence ( J:90331 )

abnormal definitive hematopoiesis ( J:90331 )

• periferal WBC counts normal

abnormal erythrocyte cell number ( J:90331 )

• decreased erythroid cells

decreased B cell number ( J:90331 )

abnormal spleen morphology ( J:90331 )

enlarged spleen ( J:90331 )

spleen hyperplasia ( J:90331 )

• hypercellularity and grossly disrupted architecture

• accumulation of immature myeloid cells

• increased numbers of progenitor cells and neutrophils

immune system

increased T cell derived lymphoma incidence ( J:90331 )

decreased B cell number ( J:90331 )

abnormal spleen morphology ( J:90331 )

enlarged spleen ( J:90331 )

spleen hyperplasia ( J:90331 )

• hypercellularity and grossly disrupted architecture

• accumulation of immature myeloid cells

• increased numbers of progenitor cells and neutrophils

liver/biliary system

enlarged liver ( J:90331 )

skeleton

abnormal bone marrow morphology ( J:90331 )

• hypercellularity and grossly disrupted architecture

• accumulation of immature myeloid cells in bone marrow and spleen

• increased numbers of progenitor cells and neutrophils

growth/size/body

enlarged liver ( J:90331 )

enlarged spleen ( J:90331 )

spleen hyperplasia ( J:90331 )

• hypercellularity and grossly disrupted architecture

• accumulation of immature myeloid cells

• increased numbers of progenitor cells and neutrophils

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:90331 )