About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smad1tm1Sor
targeted mutation 1, Philippe Soriano
MGI:3045218
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smad1tm1Sor/Smad1tm1Sor 129S4/SvJaeSor-Smad1tm1Sor MGI:3045619
hm2
 		Smad1tm1Sor/Smad1tm1Sor involves: 129S4/SvJaeSor * C57BL/6 MGI:3045617
ht3
 		Smad1tm1Sor/Smad1tm2Sor involves: 129S4/SvJaeSor * C57BL/6 MGI:3045626


Genotype
MGI:3045619
hm1
Allelic
Composition		 Smad1tm1Sor/Smad1tm1Sor
Genetic
Background		 129S4/SvJaeSor-Smad1tm1Sor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad1tm1Sor mutation (1 available); any Smad1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:90769 )
• phenotype is stated to be identical to that of homozygotes on the mixed 129S4/SvJaeSor and C57BL/6 background, however analysis is presented only on the mixed background

embryo

reproductive system

craniofacial

cardiovascular system

cellular




Genotype
MGI:3045617
hm2
Allelic
Composition		 Smad1tm1Sor/Smad1tm1Sor
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad1tm1Sor mutation (1 available); any Smad1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:90769 )
• fetuses are recovered in a Mendelian ratio until E9.5

embryo
abnormal pharyngeal arch morphology ( J:90769 )
• mutants have only one branchial arch; more severe defect than in Smad1 null mutants
caudal body truncation ( J:90769 )
• posterior truncation
rostral body truncation ( J:90769 )
• anterior truncation of the head observed in 7 of 8 fetuses; more severe than in Smad1 null mutants
abnormal allantois morphology ( J:90769 )
• defective allantois formation
• allantois growth is not as impaired as in Smad1 null mice
• allantois frequently fuses at ectopic locations rather than at the chorionic plate
abnormal extraembryonic ectoderm morphology ( J:90769 )
• marker analysis indicates the presence of ectopic extraembryonic ectoderm

reproductive system
absent primordial germ cells ( J:90769 )
• E7.5 mutants are devoid of primordial germ cells

craniofacial
abnormal pharyngeal arch morphology ( J:90769 )
• mutants have only one branchial arch; more severe defect than in Smad1 null mutants

cardiovascular system

cellular
absent primordial germ cells ( J:90769 )
• E7.5 mutants are devoid of primordial germ cells




Genotype
MGI:3045626
ht3
Allelic
Composition		 Smad1tm1Sor/Smad1tm2Sor
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad1tm1Sor mutation (1 available); any Smad1 mutation (32 available)
Smad1tm2Sor mutation (1 available); any Smad1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased primordial germ cell number ( J:90769 )
• fewer than 30% of embryos lacked primordial germ cells (compared with 100% of Smad1tm1Sor homozygotes and ~60% of Smad1tm2Sor homozygotes

cellular
decreased primordial germ cell number ( J:90769 )
• fewer than 30% of embryos lacked primordial germ cells (compared with 100% of Smad1tm1Sor homozygotes and ~60% of Smad1tm2Sor homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory