Phenotypes associated with this allele

• Allele Symbol: Fas^tm1Dlo
• Allele Name: targeted mutation 1, Dennis Y Loh
• Allele ID: MGI:3045400
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fas^tm1Dlo/Fas^tm1Dlo	involves: 129P2/OlaHsd * C57BL/6	MGI:3045618

Genotype
MGI:3045618

hm1

• Allelic Composition: Fas^tm1Dlo/Fas^tm1Dlo
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal apoptosis ( J:90750 )

• the number of apoptotic thymic epithelial cells after activation of thymocytes is significantly lower in mutant mice compared to wild-type mice

hematopoietic system

abnormal thymus involution ( J:90750 )

• decrease in thymus size, accumulation of a fatty substance, loss of defined cortico-medullary structure, or disruptive rearrangement of the T cell receptor are not seen in mutant mice as they age, indicating that normal thymic involution does not occur

enlarged spleen ( J:31847 )

• progressive enlargement of the spleen is seen

increased immunoglobulin level ( J:31847 )

• titers of total IgM, total IgG, anti-DNA IgM and anti-DNA IgG are increased

immune system

abnormal thymus involution ( J:90750 )

• decrease in thymus size, accumulation of a fatty substance, loss of defined cortico-medullary structure, or disruptive rearrangement of the T cell receptor are not seen in mutant mice as they age, indicating that normal thymic involution does not occur

enlarged spleen ( J:31847 )

• progressive enlargement of the spleen is seen

increased immunoglobulin level ( J:31847 )

• titers of total IgM, total IgG, anti-DNA IgM and anti-DNA IgG are increased

enlarged lymph nodes ( J:31847 )

• progressive enlargement of the lymph nodes is seen

• overall homozygous mutants display the same lymphoproliferative disease as Tnfrsf6^lpr mice

endocrine/exocrine glands

abnormal thymus involution ( J:90750 )

• decrease in thymus size, accumulation of a fatty substance, loss of defined cortico-medullary structure, or disruptive rearrangement of the T cell receptor are not seen in mutant mice as they age, indicating that normal thymic involution does not occur

growth/size/body

enlarged spleen ( J:31847 )

• progressive enlargement of the spleen is seen