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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nup210lTg(Gt(ROSA)26Sor-EGFP)130910Eps
transgene insertion 130910, Eric Sandgren
MGI:3045544
Summary 1 genotype


Genotype
MGI:4949538
hm1
Allelic
Composition		 Nup210lTg(Gt(ROSA)26Sor-EGFP)130910Eps/Nup210lTg(Gt(ROSA)26Sor-EGFP)130910Eps
Genetic
Background		 FVB/NTac-Nup210lTg(Gt(ROSA)26Sor-EGFP)130910Eps/Mmmh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nup210lTg(Gt(ROSA)26Sor-EGFP)130910Eps mutation (1 available); any Nup210l mutation (109 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:171266 )
N
• female mice exhibit normal reproductive morphology and fertility
teratozoospermia ( J:171266 )
• most sperm exhibits head defects and head-to-tail fusions unlike in wild-type mice
• some sperm exhibit a hook-like appearance
• older mice exhibit more severe sperm abnormalities compared with younger mice
abnormal sperm midpiece morphology ( J:171266 )
• a small piece is missing from the midpiece unlike in wild-type sperm
abnormal acrosome morphology ( J:171266 )
• incomplete in some sperm
decreased male germ cell number ( J:171266 )
• at 8 to 10 months of age
azoospermia ( J:171266 )
• at 8 to 10 months of age, no mature spermatozoa are present in the epididymal epithelium unlike in wild-type mice
asthenozoospermia ( J:171266 )
• at 8 to 10 weeks of age, sperm motility is reduced compared with wild-type sperm
• at 8 to 10 months of age, little to no sperm motility is observed compared with wild-type sperm
seminiferous tubule degeneration ( J:171266 )
• with vacuolation and rare giant cells

endocrine/exocrine glands
seminiferous tubule degeneration ( J:171266 )
• with vacuolation and rare giant cells

cellular
teratozoospermia ( J:171266 )
• most sperm exhibits head defects and head-to-tail fusions unlike in wild-type mice
• some sperm exhibit a hook-like appearance
• older mice exhibit more severe sperm abnormalities compared with younger mice
abnormal sperm midpiece morphology ( J:171266 )
• a small piece is missing from the midpiece unlike in wild-type sperm
abnormal acrosome morphology ( J:171266 )
• incomplete in some sperm
decreased male germ cell number ( J:171266 )
• at 8 to 10 months of age
azoospermia ( J:171266 )
• at 8 to 10 months of age, no mature spermatozoa are present in the epididymal epithelium unlike in wild-type mice
asthenozoospermia ( J:171266 )
• at 8 to 10 weeks of age, sperm motility is reduced compared with wild-type sperm
• at 8 to 10 months of age, little to no sperm motility is observed compared with wild-type sperm




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory