Analysis Tools|
Allele Symbol Allele Name Allele ID |
Hip1rtm1Tsr targeted mutation 1, Theodora S Ross MGI:3045594 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no gross or histological phenotype observable by 12 months of age
• mice were viable, of normal size, and were fertile, producing normal sized litters
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit more severe kypholordosis than age-matched than Hip1tm5.1(HIP1)Tsr homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• although not apparent at birth, dwarfism is noticeable by early adulthood
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• reduced body mass
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• spontaneous death in two mice at 3 months of age
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• skeletal disorganization in both thoracic and lumbar spinal regions at 13 weeks of age
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• abnormalities in spinal curvature noticeable as early as 2 weeks of age
• all mice exhibit the deformity by weaning
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• dramatically accelerated kypholordosis relative to Hip1tm3Tsr homozygotes
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• vertebral bodies show asymmetry with encroachment of cartilage into areas normally occupied by bone marrow
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit no kypholordotic spine, indicating rescue of the spinal phenotype by a single copy of human HIP1
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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