All Phenotypes Tg(TcraH-Y,TcrbH-Y)1Pas MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Lime1^tm1.1Mal/Lime1^tm1.1Mal Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraH-Y,TcrbH-Y)1Pas/?	B6.Cg-Rag2^tm1Fwa Lime1^tm1.1Mal Tg(TcraH-Y,TcrbH-Y)1Pas	MGI:3762494
cx2	Lat^{tm6.1(HBEGF/EGFP)Mal}/? Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraH-Y,TcrbH-Y)1Pas/?	involves: 129S/SvEv * 129S2/SvPas * C57BL/6	MGI:3805867
cx3	Prss16^tm1.1Mal/Prss16^tm1.1Mal Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraH-Y,TcrbH-Y)1Pas/?	involves: 129S/SvEv * 129S2/SvPas * C57BL/6	MGI:3843959
cx4	Prss16^tm1.1Mal/Prss16⁺ Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraH-Y,TcrbH-Y)1Pas/?	involves: 129S/SvEv * 129S2/SvPas * C57BL/6	MGI:3843960

Allelic Composition	Lime1^tm1.1Mal/Lime1^tm1.1Mal Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background	B6.Cg-Rag2^tm1Fwa Lime1^tm1.1Mal Tg(TcraH-Y,TcrbH-Y)1Pas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lime1^tm1.1Mal mutation (1 available); any Lime1 mutation (6 available)
Rag2^tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
Tg(TcraH-Y,TcrbH-Y)1Pas mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:126321 )

• 1.8 fold increase in clonotype positive cells in the thymus of female but not male mice

increased CD4-positive, alpha-beta T cell number ( J:126321 )

• 3 fold increase in clonotype CD4 T cells in female but not male mice

immune system

abnormal CD4-positive T cell differentiation ( J:126321 )

• 1.8 fold increase in clonotype positive cells in the thymus of female but not male mice

increased CD4-positive, alpha-beta T cell number ( J:126321 )

• 3 fold increase in clonotype CD4 T cells in female but not male mice

Allelic Composition	Lat^{tm6.1(HBEGF/EGFP)Mal}/? Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background	involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lat^{tm6.1(HBEGF/EGFP)Mal} mutation (1 available); any Lat mutation (10 available)
Rag2^tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
Tg(TcraH-Y,TcrbH-Y)1Pas mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell physiology ( J:138401 )

• T cells from this mouse strain have a high affinity for male H-Y antigen and are sensitive to diphtheria toxin

• approximately 90% depletion of these T cells occurs upon diphtheria toxin injection into a host mouse strain carrying these cells

hematopoietic system

abnormal T cell physiology ( J:138401 )

• T cells from this mouse strain have a high affinity for male H-Y antigen and are sensitive to diphtheria toxin

• approximately 90% depletion of these T cells occurs upon diphtheria toxin injection into a host mouse strain carrying these cells

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:148034 )

• thymus cellularity is reduced by more than half in female but not male mice compared to controls

abnormal positive T cell selection ( J:148034 )

• positive but not negative selection of MHC-II restricted T cells is impaired as evidenced by the low number of anti-HY (male antigen) CD4⁺T cells found in female mice

• when mice were irradiated and then reconstituted with bone marrow from OT-II mice, very few CD4⁺ T cells are produced

• when mice were irradiated and then reconstituted with bone marrow from OT-I mice, CD8⁺ T cells are produced at normal numbers

decreased double-positive T cell number ( J:148034 )

• the number of double-positive thymocytes is less than half in female but not male mice compared to controls

decreased CD4-positive, alpha-beta T cell number ( J:148034 )

• there is about a 10-fold drop peripheral CD4 T cells for female but not male mice compared to controls

decreased single-positive T cell number ( J:148034 )

• there is a large decrease (greater than 5-fold) in CD4-single positive thymocytes that express the transgenic TCR in female mice

• CD4-single positive thymocytes expressing high levels of the transgenic TCR are decreased to an even greater extent

spleen hypoplasia ( J:148034 )

• spleen cellularity is reduced by about half in female but not male mice compared to controls

lymph node hypoplasia ( J:148034 )

• there is about a 10-fold drop in lymph node cellularity for female but not male mice compared to controls

hematopoietic system

thymus hypoplasia ( J:148034 )

• thymus cellularity is reduced by more than half in female but not male mice compared to controls

abnormal positive T cell selection ( J:148034 )

• positive but not negative selection of MHC-II restricted T cells is impaired as evidenced by the low number of anti-HY (male antigen) CD4⁺T cells found in female mice

• when mice were irradiated and then reconstituted with bone marrow from OT-II mice, very few CD4⁺ T cells are produced

• when mice were irradiated and then reconstituted with bone marrow from OT-I mice, CD8⁺ T cells are produced at normal numbers

decreased double-positive T cell number ( J:148034 )

• the number of double-positive thymocytes is less than half in female but not male mice compared to controls

decreased CD4-positive, alpha-beta T cell number ( J:148034 )

• there is about a 10-fold drop peripheral CD4 T cells for female but not male mice compared to controls

decreased single-positive T cell number ( J:148034 )

• there is a large decrease (greater than 5-fold) in CD4-single positive thymocytes that express the transgenic TCR in female mice

• CD4-single positive thymocytes expressing high levels of the transgenic TCR are decreased to an even greater extent

spleen hypoplasia ( J:148034 )

• spleen cellularity is reduced by about half in female but not male mice compared to controls

endocrine/exocrine glands

thymus hypoplasia ( J:148034 )

• thymus cellularity is reduced by more than half in female but not male mice compared to controls

Allelic Composition	Prss16^tm1.1Mal/Prss16⁺ Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background	involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss16^tm1.1Mal mutation (2 available); any Prss16 mutation (41 available)
Rag2^tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
Tg(TcraH-Y,TcrbH-Y)1Pas mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal positive T cell selection ( J:148034 )

• positive but not negative selection is impaired as evidenced by the low number of anti-HY (male antigen) T cells found in female mice

decreased CD4-positive, alpha-beta T cell number ( J:148034 )

• there is about a 2-fold drop peripheral CD4 T cells for female but not male mice compared to controls

decreased single-positive T cell number ( J:148034 )

• there is a decrease (greater than 2-fold) in CD4-single positive thymocytes that express the transgenic TCR in female mice

lymph node hypoplasia ( J:148034 )

• there is about a 2-fold drop in lymph node cellularity for female but not male mice compared to controls

hematopoietic system

abnormal positive T cell selection ( J:148034 )

• positive but not negative selection is impaired as evidenced by the low number of anti-HY (male antigen) T cells found in female mice

decreased CD4-positive, alpha-beta T cell number ( J:148034 )

• there is about a 2-fold drop peripheral CD4 T cells for female but not male mice compared to controls

decreased single-positive T cell number ( J:148034 )

• there is a decrease (greater than 2-fold) in CD4-single positive thymocytes that express the transgenic TCR in female mice

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