All Phenotypes Tlr7<tm1Aki> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tlr7^tm1Aki
targeted mutation 1, Shizuo Akira
MGI:3045662

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlr7^tm1Aki/Tlr7^tm1Aki	B6.129P2-Tlr7^tm1Aki	MGI:3718579
hm2	Tlr7^tm1Aki/Tlr7^tm1Aki	involves: 129P2/OlaHsd	MGI:6403490
hm3	Tlr7^tm1Aki/Tlr7^tm1Aki	involves: 129P2/OlaHsd * C57BL/6	MGI:3799681
cx4	Nba10^NZB/Nba10^NZB Tlr7^tm1Aki/Y X/Yaa	B6.Cg-Nba10^NZB Tlr7^tm1Aki Yaa	MGI:3804683
cx5	Tlr3^tm1Aki/Tlr3^tm1Aki Tlr7^tm1Aki/Tlr7^tm1Aki	involves: 129P2/OlaHsd	MGI:6403489
cx6	Smcr8^em1Btlr/Smcr8^em1Btlr Tlr3^tm1Flv/Tlr3^tm1Flv Tlr7^tm1Aki/Tlr7^tm1Aki Tlr9^tm1Aki/Tlr9^tm1Aki	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J	MGI:6272653
cx7	Tlr7^tm1Aki/Tlr7^tm1Aki Unc93b1^tm1.1Kmiy/Unc93b1^tm1.1Kmiy	involves: 129P2/OlaHsd * C57BL/6	MGI:5140970

Allelic Composition	Tlr7^tm1Aki/Tlr7^tm1Aki
Genetic Background	B6.129P2-Tlr7^tm1Aki

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr7^tm1Aki mutation (3 available); any Tlr7 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal dendritic cell physiology ( J:118954 )

• following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40 relative to wild-type mice

decreased interleukin-12b secretion ( J:118954 )

• following infection with attenuated yellow fever vaccine 17D (YF-17D), dendritic cells produce less IL-12p40 relative to wild-type mice

Allelic Composition	Tlr7^tm1Aki/Tlr7^tm1Aki
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr7^tm1Aki mutation (3 available); any Tlr7 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interferon-alpha secretion ( J:144400 )

• bone marrow-derived plasmacytoid dendritic cells infected with a low dose of murine hepatitis virus A59 are not able to produce IFN-alpha compared to wild-type mice that show IFN-alpha production

Allelic Composition	Tlr7^tm1Aki/Tlr7^tm1Aki
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr7^tm1Aki mutation (3 available); any Tlr7 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:137066 )

N	• serum levels of IgM and IgG3 are comparable to wild-type levels at 8 weeks of age

Allelic Composition	Nba10^NZB/Nba10^NZB Tlr7^tm1Aki/Y X/Yaa
Genetic Background	B6.Cg-Nba10^NZB Tlr7^tm1Aki Yaa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nba10^NZB mutation (1 available); any Nba10 mutation (1 available)
Tlr7^tm1Aki mutation (3 available); any Tlr7 mutation (20 available)
Yaa mutation (24 available); any Yaa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased monocyte cell number ( J:137656 )

• 20% monocytosis incidence in males

• monocytosis incidence is decreased compared to C57BL/6-Nba2^NZB Yaa males (71% incidence)

abnormal immune serum protein physiology ( J:137656 )

• increased production of retroviral gp70 immune complex compared to wild-type males

increased anti-chromatin antibody level ( J:137656 )

glomerulonephritis ( J:137656 )

• 25% incidence of lethal lupus nephritis in males by 14 months of age

• decreased susceptibility to lupus nephritis and decreased glomerular lesion scores compared to C57BL/6-Nba2 Yaa males

• increased glomerular lesion score compared to wild-type males

renal/urinary system

glomerulonephritis ( J:137656 )

• 25% incidence of lethal lupus nephritis in males by 14 months of age

• decreased susceptibility to lupus nephritis and decreased glomerular lesion scores compared to C57BL/6-Nba2 Yaa males

• increased glomerular lesion score compared to wild-type males

hematopoietic system

increased monocyte cell number ( J:137656 )

• 20% monocytosis incidence in males

• monocytosis incidence is decreased compared to C57BL/6-Nba2^NZB Yaa males (71% incidence)

Allelic Composition	Tlr3^tm1Aki/Tlr3^tm1Aki Tlr7^tm1Aki/Tlr7^tm1Aki
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr3^tm1Aki mutation (2 available); any Tlr3 mutation (68 available)
Tlr7^tm1Aki mutation (3 available); any Tlr7 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interferon-alpha secretion ( J:144400 )

• bone marrow-derived plasmacytoid dendritic cells infected with a low dose of murine hepatitis virus A59 are not able to produce IFN-alpha compared to wild-type mice that show IFN-alpha production

Allelic Composition	Smcr8^em1Btlr/Smcr8^em1Btlr Tlr3^tm1Flv/Tlr3^tm1Flv Tlr7^tm1Aki/Tlr7^tm1Aki Tlr9^tm1Aki/Tlr9^tm1Aki
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smcr8^em1Btlr mutation (0 available); any Smcr8 mutation (40 available)
Tlr3^tm1Flv mutation (6 available); any Tlr3 mutation (68 available)
Tlr7^tm1Aki mutation (3 available); any Tlr7 mutation (20 available)
Tlr9^tm1Aki mutation (7 available); any Tlr9 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:268243 )

N	• unlike in Smcr8^em1Btlr homozygotes, spleen and lymph nodes are restored to normal as well as is the hyperactivation of T cells and increased circulating IL12p40 levels

Allelic Composition	Tlr7^tm1Aki/Tlr7^tm1Aki Unc93b1^tm1.1Kmiy/Unc93b1^tm1.1Kmiy
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr7^tm1Aki mutation (3 available); any Tlr7 mutation (20 available)
Unc93b1^tm1.1Kmiy mutation (6 available); any Unc93b1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:174308 )

N	• unlike Unc93b1^tm1.1Kmiy homozygotes, mice do not exhibit premature death

hematopoietic system

hematopoietic system phenotype ( J:174308 )

N	• unlike Unc93b1^tm1.1Kmiy homozygotes, mice do not exhibit expansion of erythroblasts and myeloid cells in the spleen • unlike Unc93b1^tm1.1Kmiy homozygotes, mice exhibit normal platelet counts, memory T cells, and B cell maturation and expansion

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