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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Omptm1(cre)Jae
targeted mutation 1, Rudolf Jaenisch
MGI:3045687
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Robo2tm1Rilm/Robo2tm1Rilm
Or8a1btm4Mom/?
Omptm1(cre)Jae/Omp+ 		involves: 129 * 129P2/OlaHsd * 129S1/Sv MGI:5449874
cn2
 		Robo2tm1Rilm/Robo2tm1Rilm
Omptm1(cre)Jae/Omp+ 		involves: 129 * 129S1/Sv MGI:5449871
cn3
 		Robo2tm1Rilm/Robo2tm1Rilm
Or5d18tm1.1Jfcl/?
Omptm1(cre)Jae/Omp+ 		involves: 129 * 129S1/Sv MGI:5449872
cn4
 		Robo2tm1Rilm/Robo2tm1Rilm
Or51b4tm1.1Jfcl/?
Omptm1(cre)Jae/Omp+ 		involves: 129 * 129S1/Sv MGI:5449875
cn5
 		Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp
Omptm1(cre)Jae/Omp+ 		involves: 129S1/Sv MGI:5775111
cn6
 		Kirrel2tm2c(KOMP)Wtsi/Kirrel2tm2c(KOMP)Wtsi
Omptm1(cre)Jae/Omp+ 		involves: 129S1/Sv * C57BL/6N MGI:6287118


Genotype
MGI:5449874
cn1
Allelic
Composition		 Robo2tm1Rilm/Robo2tm1Rilm
Or8a1btm4Mom/?
Omptm1(cre)Jae/Omp+
Genetic
Background		 involves: 129 * 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(cre)Jae mutation (0 available); any Omp mutation (27 available)
Or8a1btm4Mom mutation (1 available); any Or8a1b mutation (35 available)
Robo2tm1Rilm mutation (1 available); any Robo2 mutation (101 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:173325 )
• an additional lacZ positive glomerulus is detected on the dorsolateral side of the olfactory bulb, only the glomerulus on the medial side is detected in controls




Genotype
MGI:5449871
cn2
Allelic
Composition		 Robo2tm1Rilm/Robo2tm1Rilm
Omptm1(cre)Jae/Omp+
Genetic
Background		 involves: 129 * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(cre)Jae mutation (0 available); any Omp mutation (27 available)
Robo2tm1Rilm mutation (1 available); any Robo2 mutation (101 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal sensory capabilities/reflexes/nociception ( J:173325 )
• display a reduced aversive response and decreased innate avoidance behavior to the predator odorant TMT, a component of fox feces
• however, the responses to 2MB acid, an odorant of spoiled food, are similar to controls
• mice can be conditioned to respond to TMT indicating there is not a defect in detection of this odorant




Genotype
MGI:5449872
cn3
Allelic
Composition		 Robo2tm1Rilm/Robo2tm1Rilm
Or5d18tm1.1Jfcl/?
Omptm1(cre)Jae/Omp+
Genetic
Background		 involves: 129 * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(cre)Jae mutation (0 available); any Omp mutation (27 available)
Or5d18tm1.1Jfcl mutation (0 available); any Or5d18 mutation (14 available)
Robo2tm1Rilm mutation (1 available); any Robo2 mutation (101 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:173325 )
• olfactory sensory neurons expressing GFP are shifted ventrally in the olfactory bulb compared to controls
• in some mice (3 of 12) a third GFP positive glomerulus is detected on the lateral side of the olfactory bulb, a third glomerulus is only seen in 1 control




Genotype
MGI:5449875
cn4
Allelic
Composition		 Robo2tm1Rilm/Robo2tm1Rilm
Or51b4tm1.1Jfcl/?
Omptm1(cre)Jae/Omp+
Genetic
Background		 involves: 129 * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(cre)Jae mutation (0 available); any Omp mutation (27 available)
Or51b4tm1.1Jfcl mutation (0 available); any Or51b4 mutation (10 available)
Robo2tm1Rilm mutation (1 available); any Robo2 mutation (101 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:173325 )
N
• location of glomeruli from olfactory sensory neurons expressing lacZ is similar to controls




Genotype
MGI:5775111
cn5
Allelic
Composition		 Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp
Omptm1(cre)Jae/Omp+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(cre)Jae mutation (0 available); any Omp mutation (27 available)
Pgrmc1tm1.1Jjp mutation (0 available); any Pgrmc1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal sensory capabilities/reflexes/nociception ( J:223366 )
• female mice exhibit constant attraction behavior to recombinant major urinary proteins (rMUPs), in both estrus and diestrus unlike wild-type mice

nervous system
nervous system phenotype ( J:223366 )
N
• vomeronasal sensory neurons (VSNs) from ovariectomized mice exhibit normal response to recombinant major urinary proteins (rMUPs), even in the presence of diestrous levels of P4
• VSNs from diestrous-staged female mice exhibit responsiveness to rMUPs across both estrus and diestrus

taste/olfaction
taste/olfaction phenotype ( J:223366 )
N
• vomeronasal sensory neurons (VSNs) from ovariectomized mice exhibit normal response to recombinant major urinary proteins (rMUPs), even in the presence of diestrous levels of P4
• VSNs from diestrous-staged female mice exhibit responsiveness to rMUPs across both estrus and diestrus




Genotype
MGI:6287118
cn6
Allelic
Composition		 Kirrel2tm2c(KOMP)Wtsi/Kirrel2tm2c(KOMP)Wtsi
Omptm1(cre)Jae/Omp+
Genetic
Background		 involves: 129S1/Sv * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kirrel2tm2c(KOMP)Wtsi mutation (0 available); any Kirrel2 mutation (25 available)
Omptm1(cre)Jae mutation (0 available); any Omp mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb glomerular layer morphology ( J:272414 )
• adult mice show defects in glomeruli formation with significantly larger and fewer glomeruli in the posterior region of the accessory olfactory bulb (AOB) relative to controls
• in contrast, the anterior AOB region contains glomeruli of normal size and number




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory